dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006235
Uniprot Accession P16622; HEMH_YEAST; D6W2N2;
Genbank Protein ID NP_014819.3;
Genbank Nucleotide ID NM_001183595.3;
Protein Name Ferrochelatase, mitochondrial
Protein Synonyms/Alias Heme synthase;Protoheme ferro-lyase;
Gene Name HEM15
Gene Synonyms/Alias YOR176W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Catalyzes the ferrous insertion into protoporphyrin IX.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
102YREIGGGSPIRKWSEdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22369663; 22817900; 19823750;
Sequence
(Fasta)
MLSRTIRTQG SFLRRSQLTI TRSFSVTFNM QNAQKRSPTG IVLMNMGGPS KVEETYDFLY 60
QLFADNDLIP ISAKYQKTIA KYIAKFRTPK IEKQYREIGG GSPIRKWSEY QATEVCKILD 120
KTCPETAPHK PYVAFRYAKP LTAETYKQML KDGVKKAVAF SQYPHFSYST TGSSINELWR 180
QIKALDSERS ISWSVIDRWP TNEGLIKAFS ENITKKLQEF PQPVRDKVVL LFSAHSLPMD 240
VVNTGDAYPA EVAATVYNIM QKLKFKNPYR LVWQSQVGPK PWLGAQTAEI AEFLGPKVDG 300
LMFIPIAFTS DHIETLHEID LGVIGESEYK DKFKRCESLN GNQTFIEGMA DLVKSHLQSN 360
QLYSNQLPLD FALGKSNDPV KDLSLVFGNH EST 394
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0350--Heme biosynthesis
KW-0408--Iron
KW-0456--Lyase
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0627--Porphyrin biosynthesis
KW-1185--Reference proteome
KW-0809--Transit peptide

Interpro

IPR001015--Ferrochelatase
IPR019772--Ferrochelatase_AS

PROSITE

PS00534--FERROCHELATASE

Pfam

PF00762--Ferrochelatase

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0004325--F:ferrochelatase activity
GO:0006783--P:heme biosynthetic process