| Tag |
Content |
| dbPAF ID |
dbPAF-0006234 |
| Uniprot Accession |
P16621; LAR_DROME; Q960M3; Q9VIS8;
|
| Genbank Protein ID |
NP_523604.2;
|
| Genbank Nucleotide ID |
NM_078880.3;
|
| Protein Name |
Tyrosine-protein phosphatase Lar |
| Protein Synonyms/Alias |
Protein-tyrosine-phosphate phosphohydrolase;dLAR; |
| Gene Name |
Lar |
| Gene Synonyms/Alias |
CG10443; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance.Functional Description
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MGLQMTAARP IAALSLLVLS LLTWTHPTIV DAAHPPEIIR KPQNQGVRVG GVASFYCAAR 60
GDPPPSIVWR KNGKKVSGTQ SRYTVLEQPG GISILRIEPV RAGRDDAPYE CVAENGVGDA 120
VSADATLTIY EGDKTPAGFP VITQGPGTRV IEVGHTVLMT CKAIGNPTPN IYWIKNQTKV 180
DMSNPRYSLK DGFLQIENSR EEDQGKYECV AENSMGTEHS KATNLYVKVR RVPPTFSRPP 240
ETISEVMLGS NLNLSCIAVG SPMPHVKWMK GSEDLTPENE MPIGRNVLQL INIQESANYT 300
CIAASTLGQI DSVSVVKVQS LPTAPTDVQI SEVTATSVRL EWSYKGPEDL QYYVIQYKPK 360
NANQAFSEIS GIITMYYVVR ALSPYTEYEF YVIAVNNIGR GPPSAPATCT TGETKMESAP 420
RNVQVRTLSS STMVITWEPP ETPNGQVTGY KVYYTTNSNQ PEASWNSQMV DNSELTTVSE 480
LTPHAIYTVR VQAYTSMGAG PMSTPVQVKA QQGVPSQPSN FRATDIGETA VTLQWTKPTH 540
SSENIVHYEL YWNDTYANQA HHKRISNSEA YTLDGLYPDT LYYIWLAARS QRGEGATTPP 600
IPVRTKQYVP GAPPRNITAI ATSSTTISLS WLPPPVERSN GRIIYYKVFF VEVGREDDEA 660
TTMTLNMTSI VLDELKRWTE YKIWVLAGTS VGDGPRSHPI ILRTQEDVPG DPQDVKATPL 720
NSTSIHVSWK PPLEKDRNGI IRGYHIHAQE LRDEGKGFLN EPFKFDVVDT LEFNVTGLQP 780
DTKYSIQVAA LTRKGDGDRS AAIVVKTPGG VPVRPTVSLK IMEREPIVSI ELEWERPAQT 840
YGELRGYRLR WGVKDQALKE EMLSGPQMTK KRFDNLERGV EYEFRVAGSN HIGIGQETVK 900
IFQTPEGTPG GPPSNITIRF QTPDVLCVTW DPPTREHRNG IITRYDVQFH KKIDHGLGSE 960
RNMTLRKAVF TNLEENTEYI FRVRAYTKQG AGPFSDKLIV ETERDMGRAP MSLQAEATSE 1020
QTAEIWWEPV TSRGKLLGYK IFYTMTAVED LDDWQTKTVG LTESADLVNL EKFAQYAVAI 1080
AARFKNGLGR LSEKVTVRIK PEDVPLNLRA HDVSTHSMTL SWSPPIRLTP VNYKISFDAM 1140
KVFVDSQGFS QTQIVPKREI ILKHYVKTHT INELSPFTTY NVNVSAIPSD YSYRPPTKIT 1200
VTTQMAAPQP MVKPDFYGVV NGEEILVILP QASEEYGPIS HYYLVVVPED KSNLHKIPDQ 1260
FLTDDLLPGR NKPERPNAPY IAAKFPQRSI PFTFHLGSGD DYHNFTNRKL EREKRYRIFV 1320
RAVVDTPQKH LYTSSPFSEF LSLDMREAPP GERPHRPDPN WPAEPEVSVN RNKDEPEILW 1380
VVLPLMVSTF IVSTALIVLC VVKRRRQPCK TPDQAAVTRP LMAADLGAGP TPSDPVDMRR 1440
LNFQTPGMIS HPPIPISEFA NHIERLKSND NQKFSQEYES IEPGQQFTWD NSNLEHNKSK 1500
NRYANVTAYD HSRVQLPAVE GVVGSDYINA NYCDGYRKHN AYVATQGPLQ ETFVDFWRMC 1560
WELKTATIVM MTRLEERTRI KCDQYWPTRG TETYGQIFVT ITETQELATY SIRTFQLCRQ 1620
GFNDRREIKQ LQFTAWPDHG VPDHPAPFLQ FLRRCRALTP PESGPVIVHC SAGVGRTGCY 1680
IVIDSMLERM KHEKIIDIYG HVTCLRAQRN YMVQTEDQYI FIHDAILEAI ICGVTEVPAR 1740
NLHTHLQKLL ITEPGETISG MEVEFKKLSN VKMDSSKFVT ANLPCNKHKN RLVHILPYES 1800
SRVYLTPIHG IEGSDYVNAS FIDGYRYRSA YIAAQGPVQD AAEDFWRMLW EHNSTIVVML 1860
TKLKEMGREK CFQYWPHERS VRYQYYVVDP IAEYNMPQYK LREFKVTDAR DGSSRTVRQF 1920
QFIDWPEQGV PKSGEGFIDF IGQVHKTKEQ FGQDGPITVH CSAGVGRSGV FITLSIVLER 1980
MQYEGVLDVF QTVRILRSQR PAMVQTEDQY HFCYRAALEY LGSFDNYTN
Fasta Sequence
>P16621|Lar|Drosophila melanogaster(Fruit fly)
MGLQMTAARPIAALSLLVLSLLTWTHPTIVDAAHPPEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRYTVLEQPGGISILRIEPVRAGRDDAPYECVAENGVGDAVSADATLTIYEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNVLQLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGETKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYVPGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYTN
|
| Keyword |
KW-0002--3D-structure
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0358--Heparin-binding
KW-0378--Hydrolase
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR003961--FN3_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003598--Ig_sub2
IPR029021--Prot-tyrosine_phosphatase-like
IPR000242--PTPase_domain
IPR016130--Tyr_Pase_AS
IPR000387--TYR_PHOSPHATASE_dom
|
| PROSITE |
PS50853--FN3
PS50835--IG_LIKE
PS00383--TYR_PHOSPHATASE_1
PS50056--TYR_PHOSPHATASE_2
PS50055--TYR_PHOSPHATASE_PTP
|
| Pfam |
PF00041--fn3
PF07679--I-set
PF00102--Y_phosphatase
|
| Gene Ontology |
GO:0030424--C:axon
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0005875--C:microtubule associated complex
GO:0005886--C:plasma membrane
GO:0008201--F:heparin binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0032093--F:SAM domain binding
GO:0005001--F:transmembrane receptor protein tyrosine phosphatase activity
GO:0048675--P:axon extension
GO:0007411--P:axon guidance
GO:0007412--P:axon target recognition
GO:0007155--P:cell adhesion
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0008045--P:motor neuron axon guidance
GO:1903386--P:negative regulation of homophilic cell adhesion
GO:0007399--P:nervous system development
GO:0048477--P:oogenesis
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0008594--P:photoreceptor cell morphogenesis
GO:0006470--P:protein dephosphorylation
GO:0045467--P:R7 cell development
GO:0048841--P:regulation of axon extension involved in axon guidance
GO:0008360--P:regulation of cell shape
GO:0031290--P:retinal ganglion cell axon guidance
GO:0007283--P:spermatogenesis
GO:0051124--P:synaptic growth at neuromuscular junction
|
