dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006225
Uniprot Accession P16568; BICD_DROME; Q9VJD5;
Genbank Protein ID NP_001260530.1; NP_724056.1;
Genbank Nucleotide ID NM_001273601.1; NM_165220.3;
Protein Name Protein bicaudal D
Protein Synonyms/Alias
Gene Name BicD
Gene Synonyms/Alias CG6605;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
103EDALLNESAARETSLdbPTM 3.0;Phospho.ELM 9.0;UniProt;curated17372656; 18327897; 16381945; 23193290; 19234596; 22817900
285SNMEDNASNNSDGEEdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
288EDNASNNSDGEEENLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
305KRLEADLSTELKSPDdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
306RLEADLSTELKSPDGdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
310DLSTELKSPDGTKCDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
314ELKSPDGTKCDLFSEPHOSIDA;curated21081558; 22817900
528DHKTDDMSFENDSLTdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
533DMSFENDSLTAIQSQPHOSIDA;curated21081558; 22817900
Sequence
(Fasta)		MSSASNNGPS ADQSVQDLQM EVERLTRELD QVSSASAQSA QYGLSLLEEK SALQQKCEEL 60
ETLYDNTRHE LDITQEALTK FQTSQKVTNK TGIEQEDALL NESAARETSL NLQIFDLENE 120
LKQLRHELER VRNERDRMLQ ENSDFGRDKS DSEADRLRLK SELKDLKFRE TRMLSEYSEL 180
EEENISLQKQ VSSLRSSQVE FEGAKHEIRR LTEEVELLNQ QVDELANLKK IAEKQMEEAL 240
ETLQGEREAK YALKKELDGH LNRESMYHIS NLAYSIRSNM EDNASNNSDG EEENLALKRL 300
EADLSTELKS PDGTKCDLFS EIHLNELKKL EKQLESMESE KTHLTANLRE AQTSLDKSQN 360
ELQNFMSRLA LLAAHVDALV QLKKQIDVKE QGKEGGQKKD ELEQQLRALI SQYANWFTLS 420
AKEIDGLKTD IAELQKGLNY TDATTTLRNE VTNLKNKLLA TEQKSLDLQS DVQTLTHISQ 480
NAGQSLGSAR STLVALSDDL AQLYHLVCTV NGETPTRVLL DHKTDDMSFE NDSLTAIQSQ 540
FKSDVFIAKP QIVEDLQGLA DSVEIKKYVD TVSDQIKYLK TAVEHTIDMN KHKIRSEGGD 600
ALEKVNTEEM EELQEQIVKL KSLLSVKREQ IGTLRNVLKS NKQTAEVALT NLKSKYENEK 660
IIVSDTMSKL RNELRLLKED AATFSSLRAM FAARCEEYVT QVDDLNRQLE AAEEEKKTLN 720
QLLRLAVQQK LALTQRLEEM EMDREMRHVR RPMPAQRGTS GKSSFSTRPS SRNPASSNAN 780
PF 783
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR018477--Bicaudal-D_microtubule-assoc
PROSITE
Pfam

PF09730--BicD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0032050--F:clathrin heavy chain binding
GO:0045502--F:dynein binding
GO:0017137--F:Rab GTPase binding
GO:0070727--P:cellular macromolecule localization
GO:0007293--P:germarium-derived egg chamber formation
GO:0007294--P:germarium-derived oocyte fate determination
GO:0008298--P:intracellular mRNA localization
GO:0051028--P:mRNA transport
GO:0007314--P:oocyte anterior/posterior axis specification
GO:0007309--P:oocyte axis specification
GO:0007310--P:oocyte dorsal/ventral axis specification
GO:0016325--P:oocyte microtubule cytoskeleton organization
GO:0008103--P:oocyte microtubule cytoskeleton polarization
GO:0007312--P:oocyte nucleus migration involved in oocyte dorsal/ventral axis specification
GO:0048477--P:oogenesis
GO:2000370--P:positive regulation of clathrin-mediated endocytosis
GO:2000302--P:positive regulation of synaptic vesicle exocytosis
GO:0030100--P:regulation of endocytosis
GO:0050658--P:RNA transport
GO:0048488--P:synaptic vesicle endocytosis