| Tag |
Content |
| dbPAF ID |
dbPAF-0006222 |
| Uniprot Accession |
P16554; NUMB_DROME; B8A413; B8A419; Q8IPE9; Q961A6; Q9VLB8;
|
| Genbank Protein ID |
NP_001260291.1; NP_523523.2; NP_723460.1;
|
| Genbank Nucleotide ID |
NM_001273362.1; NM_078799.3; NM_164855.2;
|
| Protein Name |
Protein numb |
| Protein Synonyms/Alias |
|
| Gene Name |
numb |
| Gene Synonyms/Alias |
CG3779; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Required in determination of cell fate during sensory organ formation in embryos. Functions in nuclei and seems to interact with nucleic acids.Functional Description
Required in determination of cell fate during sensory organ formation in embryos. Functions in nuclei and seems to interact with nucleic acids. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MGNSSSHTHE PLERGFTRGK FGDVKNGKSA SFRFSKKSPK KMDRLRRSFR DSFRRRKDRV 60
PESSKPHQWQ ADEEAVRSAT CSFSVKYLGC VEVFESRGMQ VCEEALKVLR QSRRRPVRGL 120
LHVSGDGLRV VDDETKGLIV DQTIEKVSFC APDRNHERGF SYICRDGTTR RWMCHGFLAC 180
KDSGERLSHA VGCAFAVCLE RKQRRDKECG VTMTFDTKNS TFTRTGSFRQ QTLTERLAMA 240
TVGTNERSVD GPGSAMPGPP AATVKPFNPF AIERPHATPN MLERQSSFRL STIGSQSPFK 300
RQMSLRINDL PSNADRQRAF LTAAAGNPMQ TPLRSVSPIA EVSPAKSAGA DPLSAAAVAA 360
DSVSQLCQEL SQGLSLLTQT DALLAAGEDL NFNNNRSINQ NIIAAEKQVQ HVHSYAPPTA 420
QVTPRVASTT PTYQTLHSQS PSRSEQSIET STELPNAEQW LGHVVRSTSP AAPKRPTYLA 480
NVGRAQTLAS GTGAAVGGGG PDDPFDAEWV ANVAAAKQLS PDLPIPSTAR SPLARHSTNP 540
FISPPKAPAQ SFQVQL
557Fasta Sequence
>P16554|numb|Drosophila melanogaster(Fruit fly)
MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL
|
| Keyword |
KW-0002--3D-structure
KW-0024--Alternative initiation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR010449--Numb_domain
IPR011993--PH/PTB_dom
IPR006020--PTB/PI_dom
|
| PROSITE |
PS01179--PID
|
| Pfam |
PF06311--NumbF
PF00640--PID
|
| Gene Ontology |
GO:0045180--C:basal cortex
GO:0045178--C:basal part of cell
GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0005112--F:Notch binding
GO:0008356--P:asymmetric cell division
GO:0055059--P:asymmetric neuroblast division
GO:0045165--P:cell fate commitment
GO:0001709--P:cell fate determination
GO:0007417--P:central nervous system development
GO:0051642--P:centrosome localization
GO:0035050--P:embryonic heart tube development
GO:0008347--P:glial cell migration
GO:0007507--P:heart development
GO:0061382--P:Malpighian tubule tip cell differentiation
GO:0042694--P:muscle cell fate specification
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0007400--P:neuroblast fate determination
GO:0007405--P:neuroblast proliferation
GO:0007219--P:Notch signaling pathway
GO:0061320--P:pericardial nephrocyte differentiation
GO:0007422--P:peripheral nervous system development
GO:0045807--P:positive regulation of endocytosis
GO:0008104--P:protein localization
GO:0009786--P:regulation of asymmetric cell division
GO:0051960--P:regulation of nervous system development
GO:0050767--P:regulation of neurogenesis
GO:0008593--P:regulation of Notch signaling pathway
GO:0007622--P:rhythmic behavior
GO:0045035--P:sensory organ precursor cell division
GO:0016360--P:sensory organ precursor cell fate determination
GO:0007419--P:ventral cord development
|
