dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006221
Uniprot Accession P16550; APA1_YEAST; D6VQW6;
Genbank Protein ID NP_009880.2;
Genbank Nucleotide ID NM_001178695.1;
Protein Name Protein APA1
Protein Synonyms/Alias
Gene Name APA1
Gene Synonyms/Alias DTP;YCL050C;YCL50C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP. Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates with equal efficiency. Cannot catalyze the reverse reaction. Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange recation between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
9SIPADIASLISDKYKPhosphoGRID 2.0;curated19823750; 19795423; 26040406; 22817900
17LISDKYKSAFDNGNLcurated22817900
43DPKTSMPYLISHMPScurated26040406
46TSMPYLISHMPSLIEcurated26040406
50YLISHMPSLIEKPERcurated26040406
60EKPERGQTPEGEDPLdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
75GKPEEELTVIPEFGGcurated22817900
185GKEHFLPTFNTEPLQdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22817900
Sequence
(Fasta)		MSIPADIASL ISDKYKSAFD NGNLKFIQTE TTKTKDPKTS MPYLISHMPS LIEKPERGQT 60
PEGEDPLGKP EEELTVIPEF GGADNKAYKL LLNKFPVIPE HTLLVTNEYQ HQTDALTPTD 120
LLTAYKLLCA LDNEESDKRH MVFYNSGPAS GSSLDHKHLQ ILQMPEKFVT FQDRLCNGKE 180
HFLPTFNTEP LQDAKVSFAH FVLPMPESEE TVDEDLLAMC YISILQRALT FFQDWLNENP 240
ELKKSYNLML TKEWICVVPR SKAFSDEMKI GFNSTGYCGM ILTKNDEVFS KITEKPELIN 300
DILLECGFPN TSGQKPNEYN Y 322
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR009163--ATP_adenylyltransferase
IPR019200--ATP_adenylylTrfase_C
IPR011146--HIT-like
PROSITE
Pfam

PF09830--ATP_transf
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003877--F:ATP adenylyltransferase activity
GO:0005524--F:ATP binding
GO:0008796--F:bis(5'-nucleosyl)-tetraphosphatase activity
GO:0004780--F:sulfate adenylyltransferase (ADP) activity
GO:0009164--P:nucleoside catabolic process
GO:0009165--P:nucleotide biosynthetic process