dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006213
Uniprot Accession P16474; GRP78_YEAST; D6VWE9;
Genbank Protein ID NP_012500.3;
Genbank Nucleotide ID NM_001181468.3;
Protein Name 78 kDa glucose-regulated protein homolog
Protein Synonyms/Alias
Gene Name KAR2
Gene Synonyms/Alias GRP78;SSD1;YJL034W;J1248;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
84NEQGNRITPSYVAFTPhosphoGRID 2.021126336
152GKPAVEVSVKGEKKVPhosphoGRID 2.0;curated19823750; 19795423; 22817900
166VFTPEEISGMILGKMcurated22369663
299KKHGIDVSDNNKALAPhosphoPep 2.019060867
385DIVLVGGSTRIPKVQcurated19823750
386IVLVGGSTRIPKVQQcurated19823750
397KVQQLLESYFDGKKAcurated19823750
570EEAEKFASEDASIKAPhosphoGRID 2.021126336
574KFASEDASIKAKVESdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 24961812
588SRNKLENYAHSLKNQcurated22817900
591KLENYAHSLKNQVNGcurated22817900
660LYGGADGSGAADYDDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19366988; 22817900
665DGSGAADYDDEDEDDdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
676DEDDDGDYFEHDEL-dbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MFFNRLSAGK LLVPLSVVLY ALFVVILPLQ NSFHSSNVLV RGADDVENYG TVIGIDLGTT 60
YSCVAVMKNG KTEILANEQG NRITPSYVAF TDDERLIGDA AKNQVAANPQ NTIFDIKRLI 120
GLKYNDRSVQ KDIKHLPFNV VNKDGKPAVE VSVKGEKKVF TPEEISGMIL GKMKQIAEDY 180
LGTKVTHAVV TVPAYFNDAQ RQATKDAGTI AGLNVLRIVN EPTAAAIAYG LDKSDKEHQI 240
IVYDLGGGTF DVSLLSIENG VFEVQATSGD THLGGEDFDY KIVRQLIKAF KKKHGIDVSD 300
NNKALAKLKR EAEKAKRALS SQMSTRIEID SFVDGIDLSE TLTRAKFEEL NLDLFKKTLK 360
PVEKVLQDSG LEKKDVDDIV LVGGSTRIPK VQQLLESYFD GKKASKGINP DEAVAYGAAV 420
QAGVLSGEEG VEDIVLLDVN ALTLGIETTG GVMTPLIKRN TAIPTKKSQI FSTAVDNQPT 480
VMIKVYEGER AMSKDNNLLG KFELTGIPPA PRGVPQIEVT FALDANGILK VSATDKGTGK 540
SESITITNDK GRLTQEEIDR MVEEAEKFAS EDASIKAKVE SRNKLENYAH SLKNQVNGDL 600
GEKLEEEDKE TLLDAANDVL EWLDDNFETA IAEDFDEKFE SLSKVAYPIT SKLYGGADGS 660
GAADYDDEDE DDDGDYFEHD EL 683
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0346--Stress response
Interpro

IPR018181--Heat_shock_70_CS
IPR029048--HSP70_C
IPR029047--HSP70_peptide-bd
IPR013126--Hsp_70_fam
PROSITE

PS00014--ER_TARGET
PS00297--HSP70_1
PS00329--HSP70_2
PS01036--HSP70_3
Pfam

PF00012--HSP70
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0034099--C:luminal surveillance complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0051082--F:unfolded protein binding
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process
GO:0070880--P:fungal-type cell wall beta-glucan biosynthetic process
GO:0000742--P:karyogamy involved in conjugation with cellular fusion
GO:0031204--P:posttranslational protein targeting to membrane, translocation
GO:0006986--P:response to unfolded protein
GO:0006616--P:SRP-dependent cotranslational protein targeting to membrane, translocation