dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006188
Uniprot Accession P16387; ODPA_YEAST; D3DM87;
Genbank Protein ID NP_011105.4;
Genbank Nucleotide ID NM_001179068.3;
Protein Name Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase complex component E1 alpha;PDHE1-A;
Gene Name PDA1
Gene Synonyms/Alias YER178W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
32TRIGHVRTMATLKTTcurated23825934
254YGMGTAASRSSAMTEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated15665377; 16381945; 23193290; 19366988; 22817900
309LEYETYRYGGHSMSDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 21177495; 20702584;
313TYRYGGHSMSDPGTTdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated11875433; 15665377; 17287358; 17330950; 17563356; 17761666;
315RYGGHSMSDPGTTYRdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 21081558; 19060867;
319HSMSDPGTTYRTRDEPhosphoPep 2.0;curated19060867; 22817900; 25315811
320SMSDPGTTYRTRDEIcurated22817900; 19547744
332DEIQHMRSKNDPIAGPhosphoGRID 2.019779198
395EDVYVKGTETPTLRGPhosphoGRID 2.021126336
397VYVKGTETPTLRGRIcurated26040289
Sequence
(Fasta)		MLAASFKRQP SQLVRGLGAV LRTPTRIGHV RTMATLKTTD KKAPEDIEGS DTVQIELPES 60
SFESYMLEPP DLSYETSKAT LLQMYKDMVI IRRMEMACDA LYKAKKIRGF CHLSVGQEAI 120
AVGIENAITK LDSIITSYRC HGFTFMRGAS VKAVLAELMG RRAGVSYGKG GSMHLYAPGF 180
YGGNGIVGAQ VPLGAGLAFA HQYKNEDACS FTLYGDGASN QGQVFESFNM AKLWNLPVVF 240
CCENNKYGMG TAASRSSAMT EYFKRGQYIP GLKVNGMDIL AVYQASKFAK DWCLSGKGPL 300
VLEYETYRYG GHSMSDPGTT YRTRDEIQHM RSKNDPIAGL KMHLIDLGIA TEAEVKAYDK 360
SARKYVDEQV ELADAAPPPE AKLSILFEDV YVKGTETPTL RGRIPEDTWD FKKQGFASRD 420
421
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0324--Glycolysis
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0670--Pyruvate
KW-1185--Reference proteome
KW-0786--Thiamine pyrophosphate
KW-0809--Transit peptide
Interpro

IPR001017--DH_E1
IPR017597--Pyrv_DH_E1_asu_subgrp-y
IPR029061--THDP-binding
PROSITE
Pfam

PF00676--E1_dh
Gene Ontology

GO:0042645--C:mitochondrial nucleoid
GO:0005967--C:mitochondrial pyruvate dehydrogenase complex
GO:0005739--C:mitochondrion
GO:0004739--F:pyruvate dehydrogenase (acetyl-transferring) activity
GO:0006086--P:acetyl-CoA biosynthetic process from pyruvate
GO:0006096--P:glycolytic process
GO:0007124--P:pseudohyphal growth