Tag |
Content |
dbPAF ID |
dbPAF-0006181 |
Uniprot Accession |
P16371; GROU_DROME; A4V3F6; Q0KI08; Q7KRZ4; Q9V3F7; |
Genbank Protein ID |
NP_001189293.1; NP_524514.2; NP_733133.1; NP_733134.1; NP_733135.1; NP_996298.1; |
Genbank Nucleotide ID |
NM_001202364.1; NM_079790.5; NM_170254.3; NM_170255.4; NM_170256.2; NM_206575.3; |
Protein Name |
Protein groucho |
Protein Synonyms/Alias |
Enhancer of split m9/10 protein;E(spl)m9/10; |
Gene Name |
gro |
Gene Synonyms/Alias |
E(spl)m9/m10;CG8384; |
Organism |
Drosophila melanogaster(Fruit fly) |
NCBI Taxa ID |
7227 |
Functional Description (View all) |
Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.Functional Description
Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.
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Phosphorylation Sites
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dbPAF PTMs: 15 |
Sequence (Fasta) | MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE KLSNEKTEMQ 60 RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA DHQQQVLQAV ERAKQVTMQE 120 LNLIIGHQQQ HGIQQLLQQI HAQQVPGGPP QPMGALNPFG ALGATMGLPH GPQGLLNKPP 180 EHHRPDIKPT GLEGPAAAEE RLRNSVSPAD REKYRTRSPL DIENDSKRRK DEKLQEDEGE 240 KSDQDLVVDV ANEMESHSPR PNGEHVSMEV RDRESLNGER LEKPSSSGIK QERPPSRSGS 300 SSSRSTPSLK TKDMEKPGTP GAKARTPTPN AAAPAPGVNP KQMMPQGPPP AGYPGAPYQR 360 PADPYQRPPS DPAYGRPPPM PYDPHAHVRT NGIPHPSALT GGKPAYSFHM NGEGSLQPVP 420 FPPDALVGVG IPRHARQINT LSHGEVVCAV TISNPTKYVY TGGKGCVKVW DISQPGNKNP 480 VSQLDCLQRD NYIRSVKLLP DGRTLIVGGE ASNLSIWDLA SPTPRIKAEL TSAAPACYAL 540 AISPDSKVCF SCCSDGNIAV WDLHNEILVR QFQGHTDGAS CIDISPDGSR LWTGGLDNTV 600 RSWDLREGRQ LQQHDFSSQI FSLGYCPTGD WLAVGMENSH VEVLHASKPD KYQLHLHESC 660 VLSLRFAACG KWFVSTGKDN LLNAWRTPYG ASIFQSKETS SVLSCDISTD DKYIVTGSGD 720 KKATVYEVIY
731Fasta Sequence
>P16371|gro|Drosophila melanogaster(Fruit fly) MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLECEKLSNEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTLINQLLPFLQADHQQQVLQAVERAKQVTMQELNLIIGHQQQHGIQQLLQQIHAQQVPGGPPQPMGALNPFGALGATMGLPHGPQGLLNKPPEHHRPDIKPTGLEGPAAAEERLRNSVSPADREKYRTRSPLDIENDSKRRKDEKLQEDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVRDRESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPGAKARTPTPNAAAPAPGVNPKQMMPQGPPPAGYPGAPYQRPADPYQRPPSDPAYGRPPPMPYDPHAHVRTNGIPHPSALTGGKPAYSFHMNGEGSLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLHNEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQHDFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSLRFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYIVTGSGDKKATVYEVIY
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Keyword |
KW-0025--Alternative splicing KW-0181--Complete proteome KW-0217--Developmental protein KW-0221--Differentiation KW-0524--Neurogenesis KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0677--Repeat KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0853--WD repeat KW-0879--Wnt signaling pathway
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Interpro |
IPR005617--Groucho/TLE_N IPR009146--Groucho_enhance IPR015943--WD40/YVTN_repeat-like_dom IPR001680--WD40_repeat IPR019775--WD40_repeat_CS IPR017986--WD40_repeat_dom
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PROSITE |
PS00678--WD_REPEATS_1 PS50082--WD_REPEATS_2 PS50294--WD_REPEATS_REGION
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Pfam |
PF03920--TLE_N PF00400--WD40
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Gene Ontology |
GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0043234--C:protein complex GO:0071906--F:CRD domain binding GO:0071837--F:HMG box domain binding GO:0070491--F:repressing transcription factor binding GO:0001106--F:RNA polymerase II transcription corepressor activity GO:0003714--F:transcription corepressor activity GO:0008134--F:transcription factor binding GO:0007015--P:actin filament organization GO:0048813--P:dendrite morphogenesis GO:0046331--P:lateral inhibition GO:0090090--P:negative regulation of canonical Wnt signaling pathway GO:0045879--P:negative regulation of smoothened signaling pathway GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0030178--P:negative regulation of Wnt signaling pathway GO:0007399--P:nervous system development GO:0006355--P:regulation of transcription, DNA-templated GO:0007541--P:sex determination, primary response to X:A ratio GO:0006351--P:transcription, DNA-templated GO:0016055--P:Wnt signaling pathway
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