dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006181
Uniprot Accession P16371; GROU_DROME; A4V3F6; Q0KI08; Q7KRZ4; Q9V3F7;
Genbank Protein ID NP_001189293.1; NP_524514.2; NP_733133.1; NP_733134.1; NP_733135.1; NP_996298.1;
Genbank Nucleotide ID NM_001202364.1; NM_079790.5; NM_170254.3; NM_170255.4; NM_170256.2; NM_206575.3;
Protein Name Protein groucho
Protein Synonyms/Alias Enhancer of split m9/10 protein;E(spl)m9/10;
Gene Name gro
Gene Synonyms/Alias E(spl)m9/m10;CG8384;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.
Phosphorylation Sites
dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
205AEERLRNSVSPADREdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
207ERLRNSVSPADREKYdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
216ADREKYRTRSPLDIEPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
218REKYRTRSPLDIENDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
226PLDIENDSKRRKDEKcurated22817900
242QEDEGEKSDQDLVVDdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
256DVANEMESHSPRPNGPhosphoPep 2.0;curated19060867; 22817900
258ANEMESHSPRPNGEHdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
267RPNGEHVSMEVRDREdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;UniProt;curated18327897; 16381945; 23193290; 21081558; 22817900
275MEVRDRESLNGERLEPHOSIDA;curated21081558; 22817900
296IKQERPPSRSGSSSScurated22817900
319KDMEKPGTPGAKARTPhosphoPep 2.0;curated19060867; 22817900
326TPGAKARTPTPNAAAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
328GAKARTPTPNAAAPAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
543ACYALAISPDSKVCFcurated22817900
Sequence
(Fasta)
MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE KLSNEKTEMQ 60
RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA DHQQQVLQAV ERAKQVTMQE 120
LNLIIGHQQQ HGIQQLLQQI HAQQVPGGPP QPMGALNPFG ALGATMGLPH GPQGLLNKPP 180
EHHRPDIKPT GLEGPAAAEE RLRNSVSPAD REKYRTRSPL DIENDSKRRK DEKLQEDEGE 240
KSDQDLVVDV ANEMESHSPR PNGEHVSMEV RDRESLNGER LEKPSSSGIK QERPPSRSGS 300
SSSRSTPSLK TKDMEKPGTP GAKARTPTPN AAAPAPGVNP KQMMPQGPPP AGYPGAPYQR 360
PADPYQRPPS DPAYGRPPPM PYDPHAHVRT NGIPHPSALT GGKPAYSFHM NGEGSLQPVP 420
FPPDALVGVG IPRHARQINT LSHGEVVCAV TISNPTKYVY TGGKGCVKVW DISQPGNKNP 480
VSQLDCLQRD NYIRSVKLLP DGRTLIVGGE ASNLSIWDLA SPTPRIKAEL TSAAPACYAL 540
AISPDSKVCF SCCSDGNIAV WDLHNEILVR QFQGHTDGAS CIDISPDGSR LWTGGLDNTV 600
RSWDLREGRQ LQQHDFSSQI FSLGYCPTGD WLAVGMENSH VEVLHASKPD KYQLHLHESC 660
VLSLRFAACG KWFVSTGKDN LLNAWRTPYG ASIFQSKETS SVLSCDISTD DKYIVTGSGD 720
KKATVYEVIY 731
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0071906--F:CRD domain binding
GO:0071837--F:HMG box domain binding
GO:0070491--F:repressing transcription factor binding
GO:0001106--F:RNA polymerase II transcription corepressor activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0007015--P:actin filament organization
GO:0048813--P:dendrite morphogenesis
GO:0046331--P:lateral inhibition
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007541--P:sex determination, primary response to X:A ratio
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway