dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006180 |
| Uniprot Accession | P16370; RPB3_YEAST; D6VVQ8; |
| Genbank Protein ID | NP_012243.3; |
| Genbank Nucleotide ID | NM_001179371.3; |
| Protein Name | DNA-directed RNA polymerase II subunit RPB3 |
| Protein Synonyms/Alias | |
| Gene Name | RPB3 |
| Gene Synonyms/Alias | YIL021W; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination. |
| Phosphorylation Sites |
dbPAF PTMs: 6 |
| Sequence (Fasta) | MSEEGPQVKI REASKDNVDF ILSNVDLAMA NSLRRVMIAE IPTLAIDSVE VETNTTVLAD 60 EFIAHRLGLI PLQSMDIEQL EYSRDCFCED HCDKCSVVLT LQAFGESEST TNVYSKDLVI 120 VSNLMGRNIG HPIIQDKEGN GVLICKLRKG QELKLTCVAK KGIAKEHAKW GPAAAIEFEY 180 DPWNKLKHTD YWYEQDSAKE WPQSKNCEYE DPPNEGDPFD YKAQADTFYM NVESVGSIPV 240 DQVVVRGIDT LQKKVASILL ALTQMDQDKV NFASGDNNTA SNMLGSNEDV MMTGAEQDPY 300 SNASQMGNTG SGGYDNAW 319 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR001514--DNA-dir_RNA_pol_30-40kDasu_CS |
| PROSITE | PS00446--RNA_POL_D_30KD |
| Pfam | |
| Gene Ontology | GO:0005665--C:DNA-directed RNA polymerase II, core complex |