dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006160
Uniprot Accession P16241; CF1A_DROME; Q24460; Q86P26; Q9VRY9;
Genbank Protein ID NP_001286957.1; NP_523948.1;
Genbank Nucleotide ID NM_001300028.1; NM_079224.5;
Protein Name POU domain protein CF1A
Protein Synonyms/Alias Chorion factor 1A;CF1-A;Protein drifter;Ventral veins lacking protein;
Gene Name vvl
Gene Synonyms/Alias Cf1a;CG10037;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
190HHTLRGESPQLHIHHdbPTM 3.0;SysPTM 2.018327897; 16381945; 23193290; 19366988
Sequence
(Fasta)
MAATSYMTPP SGDLDMALGG GGYHTSSPRS AADAGEMKYM QHHHHHHAAA AAAAHHQLPS 60
SPSPNGQGNG GGLGLGSGSG LGSWSALHPD PWMQTHHTHH LPAAAAVASA ADTVKQEMSH 120
LSQQTRIQQG MASPHAAWHA PHAGHYAPTG GSPLQYHHAM NGMLHHPAHA VAAAHHQSVA 180
PLHHTLRGES PQLHIHHHMG GGDRDAISGG EEDTPTSDDL EAFAKQFKQR RIKLGFTQAD 240
VGLALGTLYG NVFSQTTICR FEALQLSFKN MCKLKPLLQK WLEEADSTTG SPTSIDKIAA 300
QGRKRKKRTS IEVSVKGALE QHFHKQPKPS AQEITSLADS LQLEKEVVRV WFCNRRQKEK 360
RMTPPNTLGG DMMDGMPPGH MHHGGYHPHH DMHGSPMGTH SHSHSPPMLS PQNMQSSAVA 420
AHQLAAH 428
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
IPR010982--Lambda_DNA-bd_dom
IPR013847--POU
IPR000327--POU_dom
IPR016362--TF_POU_3

PROSITE

PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
PS00035--POU_1
PS00465--POU_2
PS51179--POU_3

Pfam

PF00046--Homeobox
PF00157--Pou

Gene Ontology

GO:0005634--C:nucleus
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0007420--P:brain development
GO:0035284--P:brain segmentation
GO:0048813--P:dendrite morphogenesis
GO:0007425--P:epithelial cell fate determination, open tracheal system
GO:0008045--P:motor neuron axon guidance
GO:0007422--P:peripheral nervous system development
GO:0002807--P:positive regulation of antimicrobial peptide biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0048814--P:regulation of dendrite morphogenesis
GO:0006366--P:transcription from RNA polymerase II promoter