dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006093
Uniprot Accession P15807; MET8_YEAST; D6VQK9;
Genbank Protein ID NP_009772.1;
Genbank Nucleotide ID NM_001178561.1;
Protein Name Siroheme biosynthesis protein MET8
Protein Synonyms/Alias
Gene Name MET8
Gene Synonyms/Alias YBR213W;YBR1461;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
27GGGEVGLTRLYKLIPPhosphoGRID 2.021126336
30EVGLTRLYKLIPTGCPhosphoGRID 2.021126336
Sequence
(Fasta)		MVKSLQLAHQ LKDKKILLIG GGEVGLTRLY KLIPTGCKLT LVSPDLHKSI IPKFGKFIQN 60
EDQPDYREDA KRFINPNWDP TKNEIYEYIR SDFKDEYLDL EDENDAWYII MTCIPDHPES 120
ARIYHLCKER FGKQQLVNVA DKPDLCDFYF GANLEIGDRL QILISTNGLS PRFGALVRDE 180
IRNLFTQMGD LALEDAVVKL GELRRGIRLL APDDKDVKYR MDWARRCTDL FGIQHCHNID 240
VKRLLDLFKV MFQEQNCSLQ FPPRERLLSE YCSS 275
Keyword

KW-0002--3D-structure
KW-0028--Amino-acid biosynthesis
KW-0181--Complete proteome
KW-0456--Lyase
KW-0486--Methionine biosynthesis
KW-0511--Multifunctional enzyme
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0627--Porphyrin biosynthesis
KW-1185--Reference proteome
Interpro

IPR028161--Met8
IPR028162--Met8_C
IPR016040--NAD(P)-bd_dom
IPR028281--Sirohaem_synthase_central
IPR006367--Sirohaem_synthase_N
PROSITE
Pfam

PF13241--NAD_binding_7
PF14823--Sirohm_synth_C
PF14824--Sirohm_synth_M
Gene Ontology

GO:0004325--F:ferrochelatase activity
GO:0043115--F:precorrin-2 dehydrogenase activity
GO:0051266--F:sirohydrochlorin ferrochelatase activity
GO:0009086--P:methionine biosynthetic process
GO:0019354--P:siroheme biosynthetic process
GO:0000103--P:sulfate assimilation