dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006084
Uniprot Accession P15700; KCY_YEAST; D6VXR0;
Genbank Protein ID NP_012901.3;
Genbank Nucleotide ID NM_001179590.3;
Protein Name Uridylate kinase
Protein Synonyms/Alias
Gene Name URA6
Gene Synonyms/Alias SOC8;YKL024C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
41EKLVKDYSFVHLSAGcurated22369663
Sequence
(Fasta)
MTAATTSQPA FSPDQVSVIF VLGGPGAGKG TQCEKLVKDY SFVHLSAGDL LRAEQGRAGS 60
QYGELIKNCI KEGQIVPQEI TLALLRNAIS DNVKANKHKF LIDGFPRKMD QAISFERDIV 120
ESKFILFFDC PEDIMLERLL ERGKTSGRSD DNIESIKKRF NTFKETSMPV IEYFETKSKV 180
VRVRCDRSVE DVYKDVQDAI RDSL 205
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0665--Pyrimidine biosynthesis
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR000850--Adenylat/UMP-CMP_kin
IPR027417--P-loop_NTPase
IPR006266--UMP_CMP_kinase

PROSITE

PS00113--ADENYLATE_KINASE

Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004017--F:adenylate kinase activity
GO:0005524--F:ATP binding
GO:0004127--F:cytidylate kinase activity
GO:0009041--F:uridylate kinase activity
GO:0006207--P:'de novo' pyrimidine nucleobase biosynthetic process
GO:0006139--P:nucleobase-containing compound metabolic process
GO:0046939--P:nucleotide phosphorylation
GO:0006221--P:pyrimidine nucleotide biosynthetic process