dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0006079 |
| Uniprot Accession | P15646; FBRL_YEAST; D6VRX5; P89890; |
| Genbank Protein ID | NP_010270.1; |
| Genbank Nucleotide ID | NM_001180073.1; |
| Protein Name | rRNA 2'-O-methyltransferase fibrillarin |
| Protein Synonyms/Alias | Histone-glutamine methyltransferase;U3 small nucleolar RNA-associated protein NOP1;Nucleolar protein 1;U3 snoRNA-associated protein NOP1; |
| Gene Name | NOP1 |
| Gene Synonyms/Alias | LOT3;YDL014W;D2870; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:1825809). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Involved in the biogenesis of the 18S rRNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MSFRPGSRGG SRGGSRGGFG GRGGSRGGAR GGSRGGFGGR GGSRGGARGG SRGGFGGRGG 60 SRGGARGGSR GGRGGAAGGA RGGAKVVIEP HRHAGVYIAR GKEDLLVTKN MAPGESVYGE 120 KRISVEEPSK EDGVPPTKVE YRVWNPFRSK LAAGIMGGLD ELFIAPGKKV LYLGAASGTS 180 VSHVSDVVGP EGVVYAVEFS HRPGRELISM AKKRPNIIPI IEDARHPQKY RMLIGMVDCV 240 FADVAQPDQA RIIALNSHMF LKDQGGVVIS IKANCIDSTV DAETVFAREV QKLREERIKP 300 LEQLTLEPYE RDHCIVVGRY MRSGLKK 328 |
| Keyword | KW-0181--Complete proteome |
| Interpro | IPR000692--Fibrillarin |
| PROSITE | PS00566--FIBRILLARIN |
| Pfam | PF01269--Fibrillarin |
| Gene Ontology | GO:0031428--C:box C/D snoRNP complex |