dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0006034
Uniprot Accession P15380; PUT4_YEAST; D6W343;
Genbank Protein ID NP_014993.1;
Genbank Nucleotide ID NM_001183768.1;
Protein Name Proline-specific permease
Protein Synonyms/Alias
Gene Name PUT4
Gene Synonyms/Alias YOR348C;O6345;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also function as non-specific GABA permease. Can also transport alanine and glycine.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
14FHKNNRHSAGVVTCAcurated22817900
25VTCADDVSGDGSGGDcurated22817900
45DVVQVTESPSSGSRNcurated25315811
47VQVTESPSSGSRNNHPhosphoGRID 2.020702584
56GSRNNHRSDNEKDDAcurated22817900
96VDLEKSPSVDGDSEPcurated24961812; 25315811
Sequence
(Fasta)
MVNILPFHKN NRHSAGVVTC ADDVSGDGSG GDTKKEEDVV QVTESPSSGS RNNHRSDNEK 60
DDAIRMEKIS KNQSASSNGT IREDLIMDVD LEKSPSVDGD SEPHKLKQGL QSRHVQLIAL 120
GGAIGTGLLV GTSSTLHTCG PAGLFISYII ISAVIYPIMC ALGEMVCFLP GDGSDSAGST 180
ANLVTRYVDP SLGFATGWNY FYCYVILVAA ECTAASGVVE YWTTAVPKGV WITIFLCVVV 240
ILNFSAVKVY GESEFWFASI KILCIVGLII LSFILFWGGG PNHDRLGFRY WQHPGAFAHH 300
LTGGSLGNFT DIYTGIIKGA FAFILGPELV CMTSAECADQ RRNIAKASRR FVWRLIFFYV 360
LGTLAISVIV PYNDPTLVNA LAQGKPGAGS SPFVIGIQNA GIKVLPHIIN GCILTSAWSA 420
ANAFMFASTR SLLTMAQTGQ APKCLGRINK WGVPYVAVGV SFLCSCLAYL NVSSSTADVF 480
NWFSNISTIS GFLGWMCGCI AYLRFRKAIF YNGLYDRLPF KTWGQPYTVW FSLIVIGIIT 540
ITNGYAIFIP KYWRVADFIA AYITLPIFLV LWFGHKLYTR TWRQWWLPVS EIDVTTGLVE 600
IEEKSREIEE MRLPPTGFKD KFLDALL 628
Keyword

KW-0029--Amino-acid transport
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport

Interpro

IPR004841--AA-permease/SLC12A_dom
IPR002293--AA/rel_permease1
IPR004762--Amino_acid_permease_fungi
IPR004840--Amoino_acid_permease_CS

PROSITE

PS00218--AMINO_ACID_PERMEASE_1

Pfam

PF00324--AA_permease

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005773--C:vacuole
GO:0015297--F:antiporter activity
GO:0015193--F:L-proline transmembrane transporter activity
GO:0015175--F:neutral amino acid transmembrane transporter activity
GO:0003333--P:amino acid transmembrane transport
GO:0015812--P:gamma-aminobutyric acid transport
GO:0015804--P:neutral amino acid transport
GO:0035524--P:proline transmembrane transport
GO:0015824--P:proline transport