dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006030
Uniprot Accession P15367; SEC11_YEAST; D6VVV3;
Genbank Protein ID NP_012288.1;
Genbank Nucleotide ID NM_001179544.1;
Protein Name Signal peptidase complex catalytic subunit SEC11
Protein Synonyms/Alias Secretory protein 11;Signal peptidase I;
Gene Name SEC11
Gene Synonyms/Alias YIR022W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
149IWISENKYAKFALLGcurated22817900
161LLGMLGLSALLGGE-curated22817900
Sequence
(Fasta)		MNLRFELQKL LNVCFLFASA YMFWQGLAIA TNSASPIVVV LSGSMEPAFQ RGDILFLWNR 60
NTFNQVGDVV VYEVEGKQIP IVHRVLRQHN NHADKQFLLT KGDNNAGNDI SLYANKKIYL 120
NKSKEIVGTV KGYFPQLGYI TIWISENKYA KFALLGMLGL SALLGGE 168
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0645--Protease
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR019758--Pept_S26A_signal_pept_1_CS
IPR019756--Pept_S26A_signal_pept_1_Ser-AS
IPR019759--Peptidase_S24_S26
IPR015927--Peptidase_S24_S26A/B/C
IPR001733--Peptidase_S26B
PROSITE

PS00501--SPASE_I_1
PS00761--SPASE_I_3
Pfam

PF00717--Peptidase_S24
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0005787--C:signal peptidase complex
GO:0008233--F:peptidase activity
GO:0008236--F:serine-type peptidase activity
GO:0045047--P:protein targeting to ER
GO:0006465--P:signal peptide processing