dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0006027
Uniprot Accession P15348; TOP2_DROME; Q9VIW2;
Genbank Protein ID NP_001260580.1; NP_476760.1;
Genbank Nucleotide ID NM_001273651.1; NM_057412.5;
Protein Name DNA topoisomerase 2
Protein Synonyms/Alias DNA topoisomerase II;
Gene Name Top2
Gene Synonyms/Alias CG10223;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
1064DELLKRGYRPDPVKEcurated22817900
1213AKGRKVKSMGGGAGAPHOSIDA;curated21081558; 22817900
1284IKAEPDASGDEVDEFdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
1302VEGGSKTSPKAKKAVdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
1344SKAKAKKSDDDVEEVdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
1352DDDVEEVTPRAERPGdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
1374IDYSSLFSDEEEDGGdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
1385EDGGNVGSDDDGNASdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
1392SDDDGNASDDDSPKRdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
1396GNASDDDSPKRPAKRdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
1428KRRAVIESDDDDIEIPhosphoPep 2.0;curated19060867; 22817900
1443DEDDDDDSDFNC---PhosphoPep 2.019060867
Sequence
(Fasta)		MENGNKALSI EQMYQKKSQL EHILLRPDSY IGSVEFTKEL MWVYDNSQNR MVQKEISFVP 60
GLYKIFDEIL VNAADNKQRD KSMNTIKIDI DPERNMVSVW NNGQGIPVTM HKEQKMYVPT 120
MIFGHLLTSS NYNDDEKKVT GGRNGYGAKL CNIFSTSFTV ETATREYKKS FKQTWGNNMG 180
KASDVQIKDF NGTDYTRITF SPDLAKFKMD RLDEDIVALM SRRAYDVAAS SKGVSVFLNG 240
NKLGVRNFKD YIDLHIKNTD DDSGPPIKIV HEVANERWEV ACCPSDRGFQ QVSFVNSIAT 300
YKGGRHVDHV VDNLIKQLLE VLKKKNKGGI NIKPFQVRNH LWVFVNCLIE NPTFDSQTKE 360
NMTLQQKGFG SKCTLSEKFI NNMSKSGIVE SVLAWAKFKA QNDIAKTGGR KSSKIKGIPK 420
LEDANEAGGK NSIKCTLILT EGDSAKSLAV SGLGVIGRDL YGVFPLRGKL LNVREANFKQ 480
LSENAEINNL CKIIGLQYKK KYLTEDDLKT LRYGKVMIMT DQDQDGSHIK GLLINFIHTN 540
WPELLRLPFL EEFITPIVKA TKKNEELSFY SLPEFEEWKN DTANHHTYNI KYYKGLGTST 600
SKEAKEYFQD MDRHRILFKY DGSVDDESIV MAFSKKHIES RKVWLTNHMD EVKRRKELGL 660
PERYLYTKGT KSITYADFIN LELVLFSNAD NERSIPSLVD GLKPGQRKVM FTCFKRNDKR 720
EVKVAQLSGS VAEMSAYHHG EVSLQMTIVN LAQNFVGANN INLLEPRGQF GTRLSGGKDC 780
ASARYIFTIM SPLTRLIYHP LDDPLLDYQV DDGQKIEPLW YLPIIPMVLV NGAEGIGTGW 840
STKISNYNPR EIMKNLRKMI NGQEPSVMHP WYKNFLGRME YVSDGRYIQT GNIQILSGNR 900
LEISELPVGV WTQNYKENVL EPLSNGTEKV KGIISEYREY HTDTTVRFVI SFAPGEFERI 960
HAEEGGFYRV FKLTTTLSTN QMHAFDQNNC LRRFPTAIDI LKEYYKLRRE YYARRRDFLV 1020
GQLTAQADRL SDQARFILEK CEKKLVVENK QRKAMCDELL KRGYRPDPVK EWQRRIKMED 1080
AEQADEEDEE EEEAAPSVSS KAKKEKEVDP EKAFKKLTDV KKFDYLLGMS MWMLTEEKKN 1140
ELLKQRDTKL SELESLRKKT PEMLWLDDLD ALESKLNEVE EKERAEEQGI NLKTAKALKG 1200
QKSASAKGRK VKSMGGGAGA GDVFPDPDGE PVEFKITEEI IKKMAAAAKV AQAAKEPKKP 1260
KEPKEPKVKK EPKGKQIKAE PDASGDEVDE FDAMVEGGSK TSPKAKKAVV KKEPGEKKPR 1320
QKKENGGGLK QSKIDFSKAK AKKSDDDVEE VTPRAERPGR RQASKKIDYS SLFSDEEEDG 1380
GNVGSDDDGN ASDDDSPKRP AKRGREDESS GGAKKKAPPK KRRAVIESDD DDIEIDEDDD 1440
DDSDFNC 1448
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0413--Isomerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0799--Topoisomerase
Interpro

IPR024946--Arg_repress_C-like
IPR003594--HATPase_C
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr
IPR001241--Topo_IIA
IPR013760--Topo_IIA-like_dom
IPR002205--Topo_IIA_A/C
IPR013758--Topo_IIA_A/C_ab
IPR013757--Topo_IIA_A_a
IPR013506--Topo_IIA_bsu_dom2
IPR013759--Topo_IIA_cen_dom
IPR018522--TopoIIA_CS
IPR031660--TOPRIM_C
IPR006171--Toprim_domain
PROSITE

PS00177--TOPOISOMERASE_II
PS50880--TOPRIM
Pfam

PF00204--DNA_gyraseB
PF00521--DNA_topoisoIV
PF02518--HATPase_c
PF01751--Toprim
PF16898--TOPRIM_C
Gene Ontology

GO:0008623--C:CHRAC
GO:0005694--C:chromosome
GO:0009330--C:DNA topoisomerase complex (ATP-hydrolyzing)
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0003918--F:DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0000400--F:four-way junction DNA binding
GO:0046872--F:metal ion binding
GO:0003729--F:mRNA binding
GO:0000182--F:rDNA binding
GO:0003696--F:satellite DNA binding
GO:0006342--P:chromatin silencing
GO:0006265--P:DNA topological change
GO:0006268--P:DNA unwinding involved in DNA replication
GO:0007126--P:meiotic nuclear division
GO:0051310--P:metaphase plate congression
GO:0007076--P:mitotic chromosome condensation
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0007067--P:mitotic nuclear division
GO:0000070--P:mitotic sister chromatid segregation
GO:0007052--P:mitotic spindle organization
GO:0000712--P:resolution of meiotic recombination intermediates
GO:0000819--P:sister chromatid segregation