| Tag |
Content |
| dbPAF ID |
dbPAF-0006023 |
| Uniprot Accession |
P15330; DORS_DROME; O77088; Q0E8P9; Q6AWP3; Q9VJD9; Q9VJE0;
|
| Genbank Protein ID |
NP_001163000.1; NP_001163001.1; NP_001286014.1; NP_724052.1; NP_724053.1; NP_724054.1;
|
| Genbank Nucleotide ID |
NM_001169529.1; NM_001169530.1; NM_001299085.1; NM_165217.3; NM_165218.3; NM_165219.2;
|
| Protein Name |
Embryonic polarity protein dorsal |
| Protein Synonyms/Alias |
|
| Gene Name |
dl |
| Gene Synonyms/Alias |
CG6667; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of dorsal protein in its nucleus during the blastoderm stage. Dorsal is a morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'-GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in Drosophila larvae.Functional Description
Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of dorsal protein in its nucleus during the blastoderm stage. Dorsal is a morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'-GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in Drosophila larvae. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MFPNQNNGAA PGQGPAVDGQ QSLNYNGLPA QQQQQLAQST KNVRKKPYVK ITEQPAGKAL 60
RFRYECEGRS AGSIPGVNST PENKTYPTIE IVGYKGRAVV VVSCVTKDTP YRPHPHNLVG 120
KEGCKKGVCT LEINSETMRA VFSNLGIQCV KKKDIEAALK AREEIRVDPF KTGFSHRFQP 180
SSIDLNSVRL CFQVFMESEQ KGRFTSPLPP VVSEPIFDKK AMSDLVICRL CSCSATVFGN 240
TQIILLCEKV AKEDISVRFF EEKNGQSVWE AFGDFQHTDV HKQTAITFKT PRYHTLDITE 300
PAKVFIQLRR PSDGVTSEAL PFEYVPMDSG KHTFWNLHRH LKRKPDEDLF QQILRLDAKR 360
EVQPPTIEVI DLDTPKIDVQ REIPSEMEFN HEESQQSEPA LEQEQSVQQE QYTQEQSLQQ 420
EQYTQEQSLQ QEQYLQQLEQ QQSFQLEEPM QQDQELPAQQ SFDQAIDHLP DHTSDHIPED 480
MEAADAHAEA EAHRLRSEQE KEIDTIIDEK VRELEQLDLG QQLEPRPLTA NDKITEWMKS 540
SEIEQQVHEP SPTAEADVLD SALEISKADK TLDELLETVA ELDEIYTDFK VQRDTYKNTI 600
QNELAGLQGR APLQVEDSFD DAATYTSLQI AFKNPVLIPM DDIMPPTPPM SQCAPEDAHQ 660
HYDPVEVNSQ ARKPETPMRP VPPVPPAILT IQYPPEEDKL PPLPPKRIRK QDSNAENRSI 720
EANTVQTKPS TGESPLNKRL PPAPKNPNFN TLPRQKKPGF FSKLFSRRKS KPDLAQGQEN 780
SSILDSKANS REPSIGHFNM QDPMRASLRS SKSAAPFISN PAPAKSSPVK AKKPGSKLTK 840
PVGRSVSSVS GKRPAYLNAD VVHIPLKGDS VNSLPQQQRT EGYSQSSTIS VGAGLDRRTA 900
SALQLADIPI SEGGMELVAI ADRQSLHNLV SSIEGHFNVQ LDPNLDLTEA EHFALYTSIP 960
PLAAASEFDE TSAYYAPVDA GEILTPDEVA KRLAAANGI
Fasta Sequence
>P15330|dl|Drosophila melanogaster(Fruit fly)
MFPNQNNGAAPGQGPAVDGQQSLNYNGLPAQQQQQLAQSTKNVRKKPYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPYRPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAREEIRVDPFKTGFSHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPVVSEPIFDKKAMSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGDFQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHRHLKRKPDEDLFQQILRLDAKREVQPPTIEVIDLDTPKIDVQREIPSEMEFNHEESQQSEPALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQLEEPMQQDQELPAQQSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTIIDEKVRELEQLDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDSALEISKADKTLDELLETVAELDEIYTDFKVQRDTYKNTIQNELAGLQGRAPLQVEDSFDDAATYTSLQIAFKNPVLIPMDDIMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMRPVPPVPPAILTIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANTVQTKPSTGESPLNKRLPPAPKNPNFNTLPRQKKPGFFSKLFSRRKSKPDLAQGQENSSILDSKANSREPSIGHFNMQDPMRASLRSSKSAAPFISNPAPAKSSPVKAKKPGSKLTKPVGRSVSSVSGKRPAYLNADVVHIPLKGDSVNSLPQQQRTEGYSQSSTISVGAGLDRRTASALQLADIPISEGGMELVAIADRQSLHNLVSSIEGHFNVQLDPNLDLTEAEHFALYTSIPPLAAASEFDETSAYYAPVDAGEILTPDEVAKRLAAANGI
|
| Keyword |
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002909--IPT
IPR000451--NFkB/Dor
IPR008967--p53-like_TF_DNA-bd
IPR030492--RHD_CS
IPR032397--RHD_dimer
IPR011539--RHD_DNA_bind_dom
|
| PROSITE |
PS01204--REL_1
PS50254--REL_2
|
| Pfam |
PF16179--RHD_dimer
PF00554--RHD_DNA_bind
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0033256--C:I-kappaB/NF-kappaB complex
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0070379--F:high mobility group box 1 binding
GO:0070491--F:repressing transcription factor binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0009952--P:anterior/posterior pattern specification
GO:0006952--P:defense response
GO:0009950--P:dorsal/ventral axis specification
GO:0009953--P:dorsal/ventral pattern formation
GO:0007398--P:ectoderm development
GO:0001715--P:ectodermal cell fate specification
GO:0007369--P:gastrulation
GO:0010004--P:gastrulation involving germ band extension
GO:0008354--P:germ cell migration
GO:0007507--P:heart development
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0035006--P:melanization defense response
GO:0007498--P:mesoderm development
GO:0007501--P:mesodermal cell fate specification
GO:0010629--P:negative regulation of gene expression
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0038061--P:NIK/NF-kappaB signaling
GO:0048935--P:peripheral nervous system neuron development
GO:0042387--P:plasmatocyte differentiation
GO:0006964--P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome
GO:0035206--P:regulation of hemocyte proliferation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0034097--P:response to cytokine
GO:0008063--P:Toll signaling pathway
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0007419--P:ventral cord development
|
