| Tag |
Content |
| dbPAF ID |
dbPAF-0006021 |
| Uniprot Accession |
P15315; CUP2_YEAST; D6VTY6;
|
| Genbank Protein ID |
NP_011349.3;
|
| Genbank Nucleotide ID |
NM_001181031.3;
|
| Protein Name |
Transcriptional activator protein CUP2 |
| Protein Synonyms/Alias |
Copper-fist transcription factor; |
| Gene Name |
CUP2 |
| Gene Synonyms/Alias |
ACE1;YGL166W;G1810; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Trans-acting regulatory protein that activates transcription of the CUP1 gene (metallothionein) in response to copper ions. Binds to the CUP1 UAS sequence 5'-GCTTCTTTTCCGCTGA-3'. Binds DNA only in presence of copper or silver. Copper seems to alter the conformation of the protein.Functional Description
Trans-acting regulatory protein that activates transcription of the CUP1 gene (metallothionein) in response to copper ions. Binds to the CUP1 UAS sequence 5'-GCTTCTTTTCCGCTGA-3'. Binds DNA only in presence of copper or silver. Copper seems to alter the conformation of the protein. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 135 | LGLNGRSSDVDMTTT | curated | 25315811 |
|
Sequence
(Fasta) | MVVINGVKYA CETCIRGHRA AQCTHTDGPL QMIRRKGRPS TTCGHCKELR RTKNFNPSGG 60
CMCASARRPA VGSKEDETRC RCDEGEPCKC HTKRKSSRKS KGGSCHRRAN DEAAHVNGLG 120
IADLDVLLGL NGRSSDVDMT TTLPSLKPPL QNGEIKADSI DNLDLASLDP LEQSPSISME 180
PVSINETGSA YTTTNTALND IDIPFSINEL NELYKQVSSH NSHSQ
226Fasta Sequence
>P15315|CUP2|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MVVINGVKYACETCIRGHRAAQCTHTDGPLQMIRRKGRPSTTCGHCKELRRTKNFNPSGGCMCASARRPAVGSKEDETRCRCDEGEPCKCHTKRKSSRKSKGGSCHRRANDEAAHVNGLGIADLDVLLGLNGRSSDVDMTTTLPSLKPPLQNGEIKADSIDNLDLASLDPLEQSPSISMEPVSINETGSAYTTTNTALNDIDIPFSINELNELYKQVSSHNSHSQ
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0186--Copper
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
|
| Interpro |
IPR001083--Cu_fist_DNA-bd_dom
|
| PROSITE |
PS01119--COPPER_FIST_1
PS50073--COPPER_FIST_2
|
| Pfam |
PF00649--Copper-fist
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005507--F:copper ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001202--F:RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
GO:0071280--P:cellular response to copper ion
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0046688--P:response to copper ion
GO:0006351--P:transcription, DNA-templated
|
