dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005984
Uniprot Accession P15108; HSC82_YEAST; D6W010;
Genbank Protein ID NP_013911.1;
Genbank Nucleotide ID NM_001182692.1;
Protein Name ATP-dependent molecular chaperone HSC82
Protein Synonyms/Alias 82 kDa heat shock cognate protein;Heat shock protein Hsp90 constitutive isoform;
Gene Name HSC82
Gene Synonyms/Alias YMR186W;YM8010.16;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction such as CNA2. Undergoes a functional cycle that is linked to its ATPase activity (By similarity). Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
36IFLRELISNASDALDdbPTM 3.018407956; 16381945; 23193290
47DALDKIRYQALSDPKPhosphoGRID 2.021126336
51KIRYQALSDPKQLETdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
278PLWTRNPSDITQEEYdbPTM 3.018407956; 16381945; 23193290
281TRNPSDITQEEYNAFdbPTM 3.018407956; 16381945; 23193290
293NAFYKSISNDWEDPLdbPTM 3.018407956; 16381945; 23193290
330APFDLFESKKKKNNIdbPTM 3.017563356; 18407956; 16381945; 23193290
375EDLPLNLSREMLQQNdbPTM 3.018407956; 16381945; 23193290
446LRYNSTKSVDELTSLdbPTM 3.018407956; 16381945; 23193290
452KSVDELTSLTDYVTRdbPTM 3.018407956; 16381945; 23193290
471QKNIYYITGESLKAVdbPTM 3.018407956; 16381945; 23193290
474IYYITGESLKAVEKSdbPTM 3.018407956; 16381945; 23193290
529KDFELEETDEEKAERdbPTM 3.018407956; 16381945; 23193290
547IKEYEPLTKALKDILcurated22817900
597KAQALRDSSMSSYMSdbPTM 3.0;curated17287358; 18407956; 16381945; 23193290
598AQALRDSSMSSYMSSdbPTM 3.017287358; 18407956; 16381945; 23193290
600ALRDSSMSSYMSSKKdbPTM 3.017287358; 16381945; 23193290
602RDSSMSSYMSSKKTFdbPTM 3.018407956; 16381945; 23193290
615TFEISPKSPIIKELKdbPTM 3.017330950; 17563356; 18407956; 16381945; 23193290
653ALLTSGFSLEEPTSFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)		MAGETFEFQA EITQLMSLII NTVYSNKEIF LRELISNASD ALDKIRYQAL SDPKQLETEP 60
DLFIRITPKP EEKVLEIRDS GIGMTKAELI NNLGTIAKSG TKAFMEALSA GADVSMIGQF 120
GVGFYSLFLV ADRVQVISKN NEDEQYIWES NAGGSFTVTL DEVNERIGRG TVLRLFLKDD 180
QLEYLEEKRI KEVIKRHSEF VAYPIQLLVT KEVEKEVPIP EEEKKDEEKK DEDDKKPKLE 240
EVDEEEEEKK PKTKKVKEEV QELEELNKTK PLWTRNPSDI TQEEYNAFYK SISNDWEDPL 300
YVKHFSVEGQ LEFRAILFIP KRAPFDLFES KKKKNNIKLY VRRVFITDEA EDLIPEWLSF 360
VKGVVDSEDL PLNLSREMLQ QNKIMKVIRK NIVKKLIEAF NEIAEDSEQF DKFYSAFAKN 420
IKLGVHEDTQ NRAALAKLLR YNSTKSVDEL TSLTDYVTRM PEHQKNIYYI TGESLKAVEK 480
SPFLDALKAK NFEVLFLTDP IDEYAFTQLK EFEGKTLVDI TKDFELEETD EEKAEREKEI 540
KEYEPLTKAL KDILGDQVEK VVVSYKLLDA PAAIRTGQFG WSANMERIMK AQALRDSSMS 600
SYMSSKKTFE ISPKSPIIKE LKKRVDEGGA QDKTVKDLTN LLFETALLTS GFSLEEPTSF 660
ASRINRLISL GLNIDEDEET ETAPEASTEA PVEEVPADTE MEEVD 706
Keyword

KW-0067--ATP-binding
KW-0143--Chaperone
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0346--Stress response
Interpro

IPR003594--HATPase_C
IPR019805--Heat_shock_protein_90_CS
IPR001404--Hsp90_fam
IPR020575--Hsp90_N
IPR020568--Ribosomal_S5_D2-typ_fold
PROSITE

PS00298--HSP90
Pfam

PF02518--HATPase_c
PF00183--HSP90
Gene Ontology

GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0042623--F:ATPase activity, coupled
GO:0051082--F:unfolded protein binding
GO:0006458--P:'de novo' protein folding
GO:0000492--P:box C/D snoRNP assembly
GO:0034605--P:cellular response to heat
GO:0043248--P:proteasome assembly
GO:0006457--P:protein folding
GO:0042026--P:protein refolding
GO:0000723--P:telomere maintenance