dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005968
Uniprot Accession P14922; CYC8_YEAST; D6VQB2;
Genbank Protein ID NP_009670.3;
Genbank Nucleotide ID NM_001178460.3;
Protein Name General transcriptional corepressor CYC8
Protein Synonyms/Alias Glucose repression mediator protein CYC8;
Gene Name CYC8
Gene Synonyms/Alias CRT8;SSN6;YBR112C;YBR0908;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex.
Phosphorylation Sites
 dbPAF PTMs: 44 (View all)
PositionPeptidesSourceReferences ( PMIDs )
163IGILYDRYGSLDYAEcurated22817900
165ILYDRYGSLDYAEEAcurated22817900
421NPGNINKSNGAPTNAPhosphoGRID 2.0;PhosphoPep 2.021126336; 19060867
426NKSNGAPTNASPAPPPhosphoPep 2.0;curated19060867; 25315811
429NGAPTNASPAPPPVIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 19779198; 19060867;
475QQHPAQQTPINSSATdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
700LVDAAVSSSTHTENNPhosphoGRID 2.019779198
708STHTENNTKSPRQPTPhosphoPep 2.0;curated19060867; 26040289
710HTENNTKSPRQPTHAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 18407956; 16381945; 23193290; 19823750; 19779198;
715TKSPRQPTHAIPTQAcurated22369663; 24961812; 25521595
720QPTHAIPTQAPATGIcurated19823750; 20377248
725IPTQAPATGITNAEPcurated25521595
741VKKQKLNSPNSNINKdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 21126336; 20702584;
744QKLNSPNSNINKLVNPhosphoGRID 2.0;PhosphoPep 2.0;curated20702584; 19060867; 22369663; 22817900
755KLVNTATSIEENAKSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 22369663; 22817900;
762SIEENAKSEVSNQSPcurated25315811
765ENAKSEVSNQSPAVVcurated25315811
768KSEVSNQSPAVVESNdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 19823750; 19795423;
774QSPAVVESNTNNTSQPhosphoPep 2.0;curated19060867; 24603354
776PAVVESNTNNTSQEEPhosphoPep 2.0;curated19060867; 22817900; 19823750
Sequence
(Fasta)		MNPGGEQTIM EQPAQQQQQQ QQQQQQQQQQ AAVPQQPLDP LTQSTAETWL SIASLAETLG 60
DGDRAAMAYD ATLQFNPSSA KALTSLAHLY RSRDMFQRAA ELYERALLVN PELSDVWATL 120
GHCYLMLDDL QRAYNAYQQA LYHLSNPNVP KLWHGIGILY DRYGSLDYAE EAFAKVLELD 180
PHFEKANEIY FRLGIIYKHQ GKWSQALECF RYILPQPPAP LQEWDIWFQL GSVLESMGEW 240
QGAKEAYEHV LAQNQHHAKV LQQLGCLYGM SNVQFYDPQK ALDYLLKSLE ADPSDATTWY 300
HLGRVHMIRT DYTAAYDAFQ QAVNRDSRNP IFWCSIGVLY YQISQYRDAL DAYTRAIRLN 360
PYISEVWYDL GTLYETCNNQ LSDALDAYKQ AARLDVNNVH IRERLEALTK QLENPGNINK 420
SNGAPTNASP APPPVILQPT LQPNDQGNPL NTRISAQSAN ATASMVQQQH PAQQTPINSS 480
ATMYSNGASP QLQAQAQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAHAQA 540
QAQAQAQAQA QAQAQAQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQLQP LPRQQLQQKG 600
VSVQMLNPQQ GQPYITQPTV IQAHQLQPFS TQAMEHPQSS QLPPQQQQLQ SVQHPQQLQG 660
QPQAQAPQPL IQHNVEQNVL PQKRYMEGAI HTLVDAAVSS STHTENNTKS PRQPTHAIPT 720
QAPATGITNA EPQVKKQKLN SPNSNINKLV NTATSIEENA KSEVSNQSPA VVESNTNNTS 780
QEEKPVKANS IPSVIGAQEP PQEASPAEEA TKAASVSPST KPLNTEPESS SVQPTVSSES 840
STTKANDQST AETIELSTAT VPAEASPVED EVRQHSKEEN GTTEASAPST EEAEPAASRD 900
AEKQQDETAA TTITVIKPTL ETMETVKEEA KMREEEQTSQ EKSPQENTLP RENVVRQVEE 960
DENYDD 967
Keyword

KW-0034--Amyloid
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0640--Prion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0802--TPR repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00515--TPR_1
PF13414--TPR_11
Gene Ontology

GO:0005634--C:nucleus
GO:0017053--C:transcriptional repressor complex
GO:0042826--F:histone deacetylase binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0006338--P:chromatin remodeling
GO:0035955--P:negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007070--P:negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0016584--P:nucleosome positioning
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000531--P:regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006366--P:transcription from RNA polymerase II promoter