dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005947
Uniprot Accession P14832; CYPH_YEAST; D6VSD6;
Genbank Protein ID NP_010439.1;
Genbank Nucleotide ID NM_001180462.1;
Protein Name Peptidyl-prolyl cis-trans isomerase
Protein Synonyms/Alias
Gene Name CPR1
Gene Synonyms/Alias CPH1;CYP1;SCC1;YDR155C;YD8358.10C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in histone deacetylase complexes, suggesting a function in chromatin. Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles. Regulates the meiotic gene program via the Set3C histone deacetylase complex to promote efficient sporulation, and the prolyl-isomerase activity is required for this function.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
2------MSQVYFDVEPhosphoGRID 2.021126336
23GRVVFKLYNDIVPKTPhosphoPep 2.019060867
39ENFRALCTGEKGFGYPhosphoPep 2.019060867
49KGFGYAGSPFHRVIPPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 22817900
71DFTAGNGTGGKSIYGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
142DIVKKVESLGSPSGAdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21126336; 19060867; 19366988;
145KKVESLGSPSGATKAdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 17563356; 18407956; 16381945; 23193290;
147VESLGSPSGATKARIPhosphoPep 2.0;curated19060867; 22817900; 19823750; 25882841; 20377248
150LGSPSGATKARIVVAPhosphoPep 2.0;curated19060867; 22817900; 25521595; 25315811
Sequence
(Fasta)		MSQVYFDVEA DGQPIGRVVF KLYNDIVPKT AENFRALCTG EKGFGYAGSP FHRVIPDFML 60
QGGDFTAGNG TGGKSIYGGK FPDENFKKHH DRPGLLSMAN AGPNTNGSQF FITTVPCPWL 120
DGKHVVFGEV VDGYDIVKKV ESLGSPSGAT KARIVVAKSG EL 163
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0197--Cyclosporin
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0413--Isomerase
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0813--Transport
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
Pfam

PF00160--Pro_isomerase
Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005758--C:mitochondrial intermembrane space
GO:0005634--C:nucleus
GO:0034967--C:Set3 complex
GO:0016018--F:cyclosporin A binding
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0030437--P:ascospore formation
GO:0044267--P:cellular protein metabolic process
GO:0016575--P:histone deacetylation
GO:0045836--P:positive regulation of meiotic nuclear division
GO:0006457--P:protein folding
GO:0000413--P:protein peptidyl-prolyl isomerization
GO:0015031--P:protein transport