dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0005937 | ||||||||
| Uniprot Accession | P14741; EI2BA_YEAST; D6VX91; | ||||||||
| Genbank Protein ID | NP_012951.1; | ||||||||
| Genbank Nucleotide ID | NM_001179816.1; | ||||||||
| Protein Name | Translation initiation factor eIF-2B subunit alpha | ||||||||
| Protein Synonyms/Alias | GCD complex subunit GCN3;Guanine nucleotide exchange factor subunit GCN3;Transcriptional activator GCN3;eIF-2B GDP-GTP exchange factor subunit alpha; | ||||||||
| Gene Name | GCN3 | ||||||||
| Gene Synonyms/Alias | AAS2;TIF221;YKR026C; | ||||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) | ||||||||
| NCBI Taxa ID | 559292 | ||||||||
| Functional Description (View all) |
Acts as a non-essential regulatory component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. Modulation of GCN3 regulatory function in response to amino acid availability occurs post-translationally. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MSEFNITETY LRFLEEDTEM TMPIAAIEAL VTLLRIKTPE TAAEMINTIK SSTEELIKSI 60 PNSVSLRAGC DIFMRFVLRN LHLYGDWENC KQHLIENGQL FVSRAKKSRN KIAEIGVDFI 120 ADDDIILVHG YSRAVFSLLN HAANKFIRFR CVVTESRPSK QGNQLYTLLE QKGIPVTLIV 180 DSAVGAVIDK VDKVFVGAEG VAESGGIINL VGTYSVGVLA HNARKPFYVV TESHKFVRMF 240 PLSSDDLPMA GPPLDFTRRT DDLEDALRGP TIDYTAQEYI TALITDLGVL TPSAVSEELI 300 KMWYD 306 |
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| Keyword | KW-0007--Acetylation |
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| Interpro | IPR000649--IF-2B-related |
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| PROSITE | |||||||||
| Pfam | PF01008--IF-2B |
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| Gene Ontology | GO:0005737--C:cytoplasm |