| Tag |
Content |
| dbPAF ID |
dbPAF-0005933 |
| Uniprot Accession |
P14734; FKH_DROME; Q9VAV0;
|
| Genbank Protein ID |
NP_001163762.1; NP_001287574.1; NP_524542.1;
|
| Genbank Nucleotide ID |
NM_001170291.1; NM_001300645.1; NM_079818.3;
|
| Protein Name |
Protein fork head |
| Protein Synonyms/Alias |
|
| Gene Name |
fkh |
| Gene Synonyms/Alias |
CG10002; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes.Functional Description
Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MQKLYAEPPP SSAPVSMASS GGGGPPSGGG GGGGGGGGGG PPPPSNNNPN PTSNGGSMSP 60
LARSAYTMNS MGLPVGGMSS VSPQAAATFS SSVLDSAAAV ASMSASMSAS MSASMNASMN 120
GSMGAAAMNS MGGNCMTPSS MSYASMGSPL GNMGGCMAMS AASMSAAGLS GTYGAMPPGS 180
REMETGSPNS LGRSRVDKPT TYRRSYTHAK PPYSYISLIT MAIQNNPTRM LTLSEIYQFI 240
MDLFPFYRQN QQRWQNSIRH SLSFNDCFVK IPRTPDKPGK GSFWTLHPDS GNMFENGCYL 300
RRQKRFKDEK KEAIRQLHKS PSHSSLEATS PGKKDHEDSH HMHHHHHSRL DHHQHHKEAG 360
GASIAGVNVL SAAHSKDAEA LAMLHANAEL CLSQQPQHVP THHHHQHHQL QQEELSAMMA 420
NRCHPSLITD YHSSMHPLKQ EPSGYTPSSH PFSINRLLPT ESKADIKMYD MSQYAGYNAL 480
SPLTNSHAAL GQDSYYQSLG YHAPAGTTSL
511Fasta Sequence
>P14734|fkh|Drosophila melanogaster(Fruit fly)
MQKLYAEPPPSSAPVSMASSGGGGPPSGGGGGGGGGGGGGPPPPSNNNPNPTSNGGSMSPLARSAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAVASMSASMSASMSASMNASMNGSMGAAAMNSMGGNCMTPSSMSYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATSPGKKDHEDSHHMHHHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHPFSINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYHAPAGTTSL
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR013638--Fork-head_N
IPR001766--Fork_head_dom
IPR018533--Forkhead_box_C
IPR018122--TF_fork_head_CS_1
IPR011991--WHTH_DNA-bd_dom
|
| PROSITE |
PS00657--FORK_HEAD_1
PS00658--FORK_HEAD_2
PS50039--FORK_HEAD_3
|
| Pfam |
PF00250--Forkhead
PF08430--Forkhead_N
PF09354--HNF_C
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0042023--P:DNA endoreduplication
GO:0035072--P:ecdysone-mediated induction of salivary gland cell autophagic cell death
GO:0007439--P:ectodermal digestive tract development
GO:0001706--P:endoderm formation
GO:0007443--P:Malpighian tubule morphogenesis
GO:0043066--P:negative regulation of apoptotic process
GO:0030308--P:negative regulation of cell growth
GO:0040015--P:negative regulation of multicellular organism growth
GO:0043069--P:negative regulation of programmed cell death
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061101--P:neuroendocrine cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0007431--P:salivary gland development
GO:0007435--P:salivary gland morphogenesis
GO:0006351--P:transcription, DNA-templated
|
