dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005925
Uniprot Accession P14680; YAK1_YEAST; D6VW43;
Genbank Protein ID NP_012394.1;
Genbank Nucleotide ID NM_001181574.1;
Protein Name Dual specificity protein kinase YAK1
Protein Synonyms/Alias
Gene Name YAK1
Gene Synonyms/Alias YJL141C;J0652;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Negative regulator of the cell cycle acting downstream of the cAMP-dependent protein kinase. Part of a glucose-sensing system involved in growth control in response to glucose availability. Phosphorylates POP2.
Phosphorylation Sites
 dbPAF PTMs: 26 (View all)
PositionPeptidesSourceReferences ( PMIDs )
38SMGSGRASPDNSHMGdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21081558; 19060867; 19366988;
98PWNEEKVTNSQQNLVcurated22369663
115PQYDDLNSNESLDAYUniProt;curated19779198; 22817900
118DDLNSNESLDAYRRRUniProt;curated19779198; 22369663; 22817900
127DAYRRRKSSLVVPPAdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated11875433; 17330950; 18407956; 16381945; 23193290; 21177495;
128AYRRRKSSLVVPPARdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated11875433; 17330950; 18407956; 16381945; 23193290; 21177495;
206QDFQRRQSLAATNYSPhosphoGRID 2.0;UniProt;curated19779198; 22817900
234TNSIPVMSPYRRLSAPhosphoGRID 2.021255108
240MSPYRRLSAYPPSTSPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated21177495; 19779198; 19060867; 26040406; 22369663; 22817900;
242PYRRLSAYPPSTSPPPhosphoGRID 2.0;PhosphoPep 2.0;curated21177495; 19779198; 19060867; 26040406; 22817900
245RLSAYPPSTSPPLQPPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated20489023; 19779198; 19060867; 23825934
246LSAYPPSTSPPLQPPPhosphoGRID 2.0;PhosphoPep 2.019779198; 19060867
247SAYPPSTSPPLQPPFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21177495; 20489023; 19779198;
288LQPVLNATPKFRRASdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20489023; 21126336; 21255108;
295TPKFRRASLNSKTISdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated11875433; 17287358; 16381945; 23193290; 21255108; 19366988;
298FRRASLNSKTISPLVdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
302SLNSKTISPLVSVTKPhosphoGRID 2.0;curated20489023; 21255108; 24961812
335KNPKRVLTKPSEGKCPhosphoGRID 2.021255108
410RTEYLTQSITEAKILcurated19823750
412EYLTQSITEAKILELcurated19823750
Sequence
(Fasta)		MNSSNNNDSS SSNSNMNNSL SPTLVTHSDA SMGSGRASPD NSHMGRGIWN PSYVNQGSQR 60
SPQQQHQNHH QQQQQQQQQQ QQNSQFCFVN PWNEEKVTNS QQNLVYPPQY DDLNSNESLD 120
AYRRRKSSLV VPPARAPAPN PFQYDSYPAY TSSNTSLAGN SSGQYPSGYQ QQQQQVYQQG 180
AIHPSQFGSR FVPSLYDRQD FQRRQSLAAT NYSSNFSSLN SNTNQGTNSI PVMSPYRRLS 240
AYPPSTSPPL QPPFKQLRRD EVQGQKLSIP QMQLCNSKND LQPVLNATPK FRRASLNSKT 300
ISPLVSVTKS LITTYSLCSP EFTYQTSKNP KRVLTKPSEG KCNNGFDNIN SDYILYVNDV 360
LGVEQNRKYL VLDILGQGTF GQVVKCQNLL TKEILAVKVV KSRTEYLTQS ITEAKILELL 420
NQKIDPTNKH HFLRMYDSFV HKNHLCLVFE LLSNNLYELL KQNKFHGLSI QLIRTFTTQI 480
LDSLCVLKES KLIHCDLKPE NILLCAPDKP ELKIIDFGSS CEEARTVYTY IQSRFYRAPE 540
IILGIPYSTS IDMWSLGCIV AELFLGIPIF PGASEYNQLT RIIDTLGYPP SWMIDMGKNS 600
GKFMKKLAPE ESSSSTQKHR MKTIEEFCRE YNIVEKPSKQ YFKWRKLPDI IRNYRYPKSI 660
QNSQELIDQE MQNRECLIHF LGGVLNLNPL ERWTPQQAML HPFITKQEFT GEWFPPGSSL 720
PGPSEKHDDA KGQQSEYGSA NDSSNNAGHN YVYNPSSATG GADSVDIGAI SKRKENTSGD 780
ISNNFAVTHS VQEGPTSAFN KLHIVEE 808
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0010811--P:positive regulation of cell-substrate adhesion
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006468--P:protein phosphorylation