dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0005901
Uniprot Accession P14540; ALF_YEAST; D6VXM7;
Genbank Protein ID NP_012863.1;
Genbank Nucleotide ID NM_001179626.1;
Protein Name Fructose-bisphosphate aldolase
Protein Synonyms/Alias
Gene Name FBA1
Gene Synonyms/Alias YKL060C;YKL320;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
Phosphorylation Sites
dbPAF PTMs: 38 (View all)
PositionPeptidesSourceReferences ( PMIDs )
11EQILKRKTGVIVGEDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 16381945; 23193290; 19060867; 19366988;
24EDVHNLFTYAKEHKFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19060867; 19366988; 22817900
39AIPAINVTSSSTAVAcurated25521595
40IPAINVTSSSTAVAAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812
41PAINVTSSSTAVAALdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812; 25521595
42AINVTSSSTAVAALEdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812; 25521595
43INVTSSSTAVAALEAdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
54ALEAARDSKSPIILQdbPTM 3.0;PhosphoPep 2.0;SysPTM 2.018407956; 16381945; 23193290; 19060867; 19366988
56EAARDSKSPIILQTSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 17330950; 21126336;
62KSPIILQTSNGGAAYdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988
63SPIILQTSNGGAAYFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
69TSNGGAAYFAGKGISPhosphoPep 2.019060867
76YFAGKGISNEGQNASdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 21126336; 19684113; 19823750;
83SNEGQNASIKGAIAAPhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;UniProt;curated21177495; 20702584; 19684113; 19823750; 19779198; 19795423;
93GAIAAAHYIRSIAPAPhosphoPep 2.0;curated19060867; 25315811
96AAAHYIRSIAPAYGIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
109GIPVVLHSDHCAKKLPhosphoPep 2.019060867
147SSHMLDLSEETDEENdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17287358; 18407956; 16381945; 23193290; 17330950; 19366988;
150MLDLSEETDEENISTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19060867; 19366988;
156ETDEENISTCVKYFKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
Sequence
(Fasta)
MGVEQILKRK TGVIVGEDVH NLFTYAKEHK FAIPAINVTS SSTAVAALEA ARDSKSPIIL 60
QTSNGGAAYF AGKGISNEGQ NASIKGAIAA AHYIRSIAPA YGIPVVLHSD HCAKKLLPWF 120
DGMLEADEAY FKEHGEPLFS SHMLDLSEET DEENISTCVK YFKRMAAMDQ WLEMEIGITG 180
GEEDGVNNEN ADKEDLYTKP EQVYNVYKAL HPISPNFSIA AAFGNCHGLY AGDIALRPEI 240
LAEHQKYTRE QVGCKEEKPL FLVFHGGSGS TVQEFHTGID NGVVKVNLDT DCQYAYLTGI 300
RDYVLNKKDY IMSPVGNPEG PEKPNKKFFD PRVWVREGEK TMGAKITKSL ETFRTTNTL 360
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0324--Glycolysis
KW-0456--Lyase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR013785--Aldolase_TIM
IPR006411--Fruct_bisP_bact
IPR000771--Ketose_bisP_aldolase_II

PROSITE

PS00602--ALDOLASE_CLASS_II_1
PS00806--ALDOLASE_CLASS_II_2

Pfam

PF01116--F_bP_aldolase

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0004332--F:fructose-bisphosphate aldolase activity
GO:0008270--F:zinc ion binding
GO:0006094--P:gluconeogenesis
GO:0006096--P:glycolytic process