dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005878
Uniprot Accession P14242; PMS1_YEAST; D6W197; Q2I044; Q2I045; Q45TY4; Q8TG48; Q8TG50; Q8TG54; Q8TG57;
Genbank Protein ID NP_014317.4;
Genbank Nucleotide ID NM_001182920.3;
Protein Name DNA mismatch repair protein PMS1
Protein Synonyms/Alias Postmeiotic segregation protein 1;
Gene Name PMS1
Gene Synonyms/Alias YNL082W;N2317;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
101GFRGEALSSLCGIAKcurated24961812
102FRGEALSSLCGIAKLcurated24961812
388TEVFDDRSTTHESDNPhosphoGRID 2.020702584
393DRSTTHESDNENYHTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 19060867; 19366988;
555CHQERRGSTDTEQDDPhosphoGRID 2.0;curated19779198; 22817900
556HQERRGSTDTEQDDEPhosphoGRID 2.0;curated19779198; 22817900
558ERRGSTDTEQDDEADPhosphoGRID 2.0;curated19779198; 22817900
566EQDDEADSIYAEIEPPhosphoGRID 2.0;UniProt19779198
598KDNYRSLSDGLTHRKdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
810IRCSKIRSMFAMRACcurated22817900
Sequence
(Fasta)		MTQIHQINDI DVHRITSGQV ITDLTTAVKE LVDNSIDANA NQIEIIFKDY GLESIECSDN 60
GDGIDPSNYE FLALKHYTSK IAKFQDVAKV QTLGFRGEAL SSLCGIAKLS VITTTSPPKA 120
DKLEYDMVGH ITSKTTTSRN KGTTVLVSQL FHNLPVRQKE FSKTFKRQFT KCLTVIQGYA 180
IINAAIKFSV WNITPKGKKN LILSTMRNSS MRKNISSVFG AGGMRGLEEV DLVLDLNPFK 240
NRMLGKYTDD PDFLDLDYKI RVKGYISQNS FGCGRNSKDR QFIYVNKRPV EYSTLLKCCN 300
EVYKTFNNVQ FPAVFLNLEL PMSLIDVNVT PDKRVILLHN ERAVIDIFKT TLSDYYNRQE 360
LALPKRMCSQ SEQQAQKRLK TEVFDDRSTT HESDNENYHT ARSESNQSNH AHFNSTTGVI 420
DKSNGTELTS VMDGNYTNVT DVIGSECEVS VDSSVVLDEG NSSTPTKKLP SIKTDSQNLS 480
DLNLNNFSNP EFQNITSPDK ARSLEKVVEE PVYFDIDGEK FQEKAVLSQA DGLVFVDNEC 540
HEHTNDCCHQ ERRGSTDTEQ DDEADSIYAE IEPVEINVRT PLKNSRKSIS KDNYRSLSDG 600
LTHRKFEDEI LEYNLSTKNF KEISKNGKQM SSIISKRKSE AQENIIKNKD ELEDFEQGEK 660
YLTLTVSKND FKKMEVVGQF NLGFIIVTRK VDNKYDLFIV DQHASDEKYN FETLQAVTVF 720
KSQKLIIPQP VELSVIDELV VLDNLPVFEK NGFKLKIDEE EEFGSRVKLL SLPTSKQTLF 780
DLGDFNELIH LIKEDGGLRR DNIRCSKIRS MFAMRACRSS IMIGKPLNKK TMTRVVHNLS 840
ELDKPWNCPH GRPTMRHLME LRDWSSFSKD YEI 874
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR013507--DNA_mismatch_repair_C
IPR014762--DNA_mismatch_repair_CS
IPR002099--DNA_mismatch_repair_fam
IPR003594--HATPase_C
IPR014790--MutL_C
IPR028831--Pms1/Pms2/PMS2L
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr
PROSITE

PS00058--DNA_MISMATCH_REPAIR_1
Pfam

PF01119--DNA_mis_repair
PF08676--MutL_C
Gene Ontology

GO:0032389--C:MutLalpha complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0030983--F:mismatched DNA binding
GO:0000710--P:meiotic mismatch repair
GO:0006298--P:mismatch repair