dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005865
Uniprot Accession P14164; ABF1_YEAST; D6VXH6;
Genbank Protein ID NP_012810.1;
Genbank Nucleotide ID NM_001179678.1;
Protein Name ARS-binding factor 1
Protein Synonyms/Alias Bidirectionally acting factor 1;DNA replication enhancer-binding protein OBF1;SFB-B;
Gene Name ABF1
Gene Synonyms/Alias BAF1;OBF1;REB2;SBF1;YKL112W;YKL505;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN(7)ACG-3'. Influences on genome-wide nucleosome occupancy and affects chromatin structure, and probably dynamics. As a component of the global genome repair (GGR) complex, promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Component of the regulatory network controlling mitotic and meiotic cell cycle progression.
Phosphorylation Sites
 dbPAF PTMs: 26 (View all)
PositionPeptidesSourceReferences ( PMIDs )
32HGGKKFPTLGAWYDVcurated22817900
161NDKVESRSNEVNGNNcurated25315811
189GVTIKNDTEDDSINKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 21177495; 19823750;
193KNDTEDDSINKASIDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 21177495; 19366988;
198DDSINKASIDRGLDDPHOSIDA;curated21081558; 19795423; 25315811
207DRGLDDESGPTHGNDcurated26040289
210LDDESGPTHGNDSGNcurated24961812
215GPTHGNDSGNHRHNEPHOSIDA;curated21081558; 26040289; 22817900
256NAVANVDSQSNNKHDPhosphoGRID 2.019779198
258VANVDSQSNNKHDGKdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
302VGSHGISSHSPSSIRdbPTM 3.0;SysPTM 2.018407956; 16381945; 23193290; 19366988
304SHGISSHSPSSIRDTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
445EYNDLQPSSSSNNNNPhosphoGRID 2.021126336
459NNNDGELSGTNLRSNcurated19823750; 25315811
461NDGELSGTNLRSNSIcurated19823750
465LSGTNLRSNSIDYAKPhosphoGRID 2.0;PhosphoPep 2.0;curated21126336; 19060867; 19823750; 20377248; 16445868
467GTNLRSNSIDYAKHQdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated11875433; 17330950; 18407956; 16381945; 23193290; 20702584;
478AKHQEISSAGTSSNTcurated25315811
483ISSAGTSSNTTKNVNcurated25315811
496VNNNKNDSNDDNNGNcurated26040289; 22369663; 24961812; 20377248
Sequence
(Fasta)		MDKLVVNYYE YKHPIINKDL AIGAHGGKKF PTLGAWYDVI NEYEFQTRCP IILKNSHRNK 60
HFTFACHLKN CPFKVLLSYA GNAASSETSS PSANNNTNPP GTPDHIHHHS NNMNNEDNDN 120
NNGSNNKVSN DSKLDFVTDD LEYHLANTHP DDTNDKVESR SNEVNGNNDD DADANNIFKQ 180
QGVTIKNDTE DDSINKASID RGLDDESGPT HGNDSGNHRH NEEDDVHTQM TKNYSDVVND 240
EDINVAIANA VANVDSQSNN KHDGKDDDAT NNNDGQDNNT NNDHNNNSNI NNNNVGSHGI 300
SSHSPSSIRD TSMNLDVFNS ATDDIPGPFV VTKIEPYHSH PLEDNLSLGK FILTKIPKIL 360
QNDLKFDQIL ESSYNNSNHT VSKFKVSHYV EESGLLDILM QRYGLTAEDF EKRLLSQIAR 420
RITTYKARFV LKKKKMGEYN DLQPSSSSNN NNNNDGELSG TNLRSNSIDY AKHQEISSAG 480
TSSNTTKNVN NNKNDSNDDN NGNNNNDASN LMESVLDKTS SHRYQPKKMP SVNKWSKPDQ 540
ITHSDVSMVG LDESNDGGNE NVHPTLAEVD AQEARETAQL AIDKINSYKR SIDDKNGDGH 600
NNSSRNVVDE NLINDMDSED AHKSKRQHLS DITLEERNED DKLPHEVAEQ LRLLSSHLKE 660
VENLHQNNDD DVDDVMVDVD VESQYNKNTT HHNNHHSQPH HDEEDVAGLI GKADDEEDLS 720
DENIQPELRG Q 732
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro
PROSITE
Pfam
Gene Ontology

GO:0000113--C:nucleotide-excision repair factor 4 complex
GO:0005634--C:nucleus
GO:0003688--F:DNA replication origin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0044374--F:sequence-specific DNA binding, bending
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0006338--P:chromatin remodeling
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006261--P:DNA-dependent DNA replication
GO:0070911--P:global genome nucleotide-excision repair
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter