dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0005847 |
| Uniprot Accession | P14064; HAP4_YEAST; D6VXH8; |
| Genbank Protein ID | NP_012813.1; |
| Genbank Nucleotide ID | NM_001179675.1; |
| Protein Name | Transcriptional activator HAP4 |
| Protein Synonyms/Alias | |
| Gene Name | HAP4 |
| Gene Synonyms/Alias | YKL109W;YKL465; |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID | 559292 |
| Functional Description (View all) |
Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP4 encodes a regulatory subunit of the DNA-bound complex and seems to provide the principal transcriptional activation domains. Does not bind DNA directly, but augments the binding of HAP2 and HAP3. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MTAKTFLLQA SASRPRSNHF KNEHNNIPLA PVPIAPNTNH HNNSSLEFEN DGSKKKKKSS 60 LVVRTSKHWV LPPRPRPGRR SSSHNTLPAN NTNNILNVGP NSRNSSNNNN NNNIISNRKQ 120 ASKEKRKIPR HIQTIDEKLI NDSNYLAFLK FDDLENEKFH SSASSISSPS YSSPSFSSYR 180 NRKKSEFMDD ESCTDVETIA AHNSLLTKNH HIDSSSNVHA PPTKKSKLND FDLLSLSSTS 240 SSATPVPQLT KDLNMNLNFH KIPHKASFPD SPADFSPADS VSLIRNHSLP TNLQVKDKIE 300 DLNEIKFFND FEKLEFFNKY AKVNTNNDVN ENNDLWNSYL QSMDDTTGKN SGNYQQVDND 360 DNMSLLNLPI LEETVSSGQD DKVEPDEEDI WNYLPSSSSQ QEDSSRALKK NTNSEKANIQ 420 AKNDETYLFL QDQDESADSH HHDELGSEIT LADNKFSYLP PTLEELMEEQ DCNNGRSFKN 480 FMFSNDTGID GSAGTDDDYT KVLKSKKIST SKSNANLYDL NDNNNDATAT NELDQSSFID 540 DLDEDVDFLK VQVF 555 |
| Keyword | KW-0010--Activator |
| Interpro | IPR018287--Hap4_TF_heteromerisation |
| PROSITE | |
| Pfam | PF10297--Hap4_Hap_bind |
| Gene Ontology | GO:0016602--C:CCAAT-binding factor complex |