| Tag |
Content |
| dbPAF ID |
dbPAF-0005794 |
| Uniprot Accession |
P13678; KPC3_DROME; Q9VAQ6;
|
| Genbank Protein ID |
NP_001287577.1; NP_524545.2;
|
| Genbank Nucleotide ID |
NM_001300648.1; NM_079821.4;
|
| Protein Name |
Protein kinase C |
| Protein Synonyms/Alias |
|
| Gene Name |
Pkc98E |
| Gene Synonyms/Alias |
Pkc3;CG1954; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.Functional Description
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 621 | QDEFAGFSFVNPKFG | PhosphoPep 2.0 | 19060867 |
|
Sequence
(Fasta) | MQSETAVQDL WVNLEPQGKI HVIIELKNRT DKAKAEAVVE HTVAVNKEFK ERAGFNRRRG 60
AMRRRVHQVN GHKFMATFLR QPTFCSHCRE FIWGIGKQGY QCQVCTLVVH KKCHLSVVSK 120
CPGMRDEQPA KVEMVPAGQR FNVNLPHRFV VHSYKRFTFC DHCGSLLYGL IKQGLQCETC 180
GMNVHKRCQK NVANTCGINT KQMAEILSSL GISPDKQQPR RSKYLNQQGG EDNYGASLGA 240
DGDGAPGQSF RSCALSVDSL ATSTTTMTSG YNSSSCMSLA VTGSGGVGAT GETRPGKCSL 300
LDFNFIKVLG KGSFGKVMLA EKKGTDEIYA IKVLKKDAII QDDDVDCTMT EKRILALAAN 360
HPFLTALHSC FQTPDRLFFV MEYVNGGDLM FQIQKARRFE ASRAAFYAAE VTLALQFLHT 420
HGVIYRDLKL DNILLDQEGH CKLADFGMCK EGIMNGMLTT TFCGTPDYIA PEILKEQEYG 480
ASVDWWALGV LMYEMMAGQP PFEADNEDEL FDSIMHDDVL YPVWLSREAV SILKGFLTKN 540
PEQRLGCTGD ENEIRKHPFF AKLDWKELEK RNIKPPFRPK MKNPRDANNF DAEFTKEDPV 600
LTPIGNEVVR CINQDEFAGF SFVNPKFGPE RKVY
635Fasta Sequence
>P13678|Pkc98E|Drosophila melanogaster(Fruit fly)
MQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPERKVY
|
| Keyword |
KW-0067--ATP-binding
KW-0106--Calcium
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR000961--AGC-kinase_C
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR002219--PE/DAG-bd
IPR017892--Pkinase_C
IPR014376--Prot_kin_PKC_delta
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS51285--AGC_KINASE_CTER
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
|
| Pfam |
PF00130--C1_1
PF00069--Pkinase
PF00433--Pkinase_C
|
| Gene Ontology |
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0009950--P:dorsal/ventral axis specification
GO:0007030--P:Golgi organization
GO:0007252--P:I-kappaB phosphorylation
GO:0034389--P:lipid particle organization
GO:0007616--P:long-term memory
GO:0008285--P:negative regulation of cell proliferation
GO:0048812--P:neuron projection morphogenesis
GO:0040018--P:positive regulation of multicellular organism growth
GO:0090277--P:positive regulation of peptide hormone secretion
GO:0006468--P:protein phosphorylation
GO:0045471--P:response to ethanol
|
