dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005788
Uniprot Accession P13663; DHAS_YEAST; D6VSD8;
Genbank Protein ID NP_010442.3;
Genbank Nucleotide ID NM_001180465.3;
Protein Name Aspartate-semialdehyde dehydrogenase
Protein Synonyms/Alias
Gene Name HOM2
Gene Synonyms/Alias YDR158W;YD8358.12;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
13IAGVLGATGSVGQRFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988
39LKVLGASSRSAGKKYcurated22369663
271FKNRPAPSVEQVKTCPhosphoPep 2.019060867
318RLDRNRDSGYGVSVGdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 17563356; 18407956; 16381945; 23193290; 21177495;
320DRNRDSGYGVSVGRIdbPTM 3.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 22817900;
323RDSGYGVSVGRIREDPhosphoGRID 2.0;UniProt;curated19779198; 22369663; 22817900
Sequence
(Fasta)		MAGKKIAGVL GATGSVGQRF ILLLANHPHF ELKVLGASSR SAGKKYVDAV NWKQTDLLPE 60
SATDIIVSEC KSEFFKECDI VFSGLDADYA GAIEKEFMEA GIAIVSNAKN YRREQDVPLI 120
VPVVNPEHLD IVAQKLDTAK AQGKPRPGFI ICISNCSTAG LVAPLKPLIE KFGPIDALTT 180
TTLQAISGAG FSPGVPGIDI LDNIIPYIGG EEDKMEWETK KILAPLAEDK THVKLLTPEE 240
IKVSAQCNRV AVSDGHTECI SLRFKNRPAP SVEQVKTCLK EYVCDAYKLG CHSAPKQTIH 300
VLEQPDRPQP RLDRNRDSGY GVSVGRIRED PLLDFKMVVL SHNTIIGAAG SGVLIAEILL 360
ARNLI 366
Keyword

KW-0028--Amino-acid biosynthesis
KW-0181--Complete proteome
KW-0457--Lysine biosynthesis
KW-0486--Methionine biosynthesis
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0791--Threonine biosynthesis
Interpro

IPR000319--Asp-semialdehyde_DH_CS
IPR005676--Asp_semi-ald_DH_pep-lack
IPR012080--Asp_semialdehyde_DH
IPR016040--NAD(P)-bd_dom
IPR000534--Semialdehyde_DH_NAD-bd
IPR012280--Semialdhyde_DH_dimer_dom
PROSITE

PS01103--ASD
Pfam

PF01118--Semialdhyde_dh
PF02774--Semialdhyde_dhC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004073--F:aspartate-semialdehyde dehydrogenase activity
GO:0003942--F:N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0051287--F:NAD binding
GO:0050661--F:NADP binding
GO:0006531--P:aspartate metabolic process
GO:0009090--P:homoserine biosynthetic process
GO:0009097--P:isoleucine biosynthetic process
GO:0009089--P:lysine biosynthetic process via diaminopimelate
GO:0009086--P:methionine biosynthetic process
GO:0009088--P:threonine biosynthetic process