dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0005778
Uniprot Accession P13607; ATNA_DROME; A4V366; A4V367; O61494; Q0KI37; Q7KS94; Q7KS95; Q86MY6; Q86MY7; Q86MY8; Q86MY9; Q86MZ0; Q8IN40; Q8T0L8; Q9VDG6; Q9VDG7; Q9VDG8;
Genbank Protein ID NP_001262790.1; NP_001262791.1; NP_732572.1; NP_732573.1; NP_732574.1; NP_732575.1; NP_996247.1; NP_996248.1; NP_996249.1; NP_996250.1;
Genbank Nucleotide ID NM_001275861.1; NM_001275862.2; NM_169936.3; NM_169937.3; NM_169938.3; NM_169939.2; NM_206525.3; NM_206526.3; NM_206527.3; NM_206528.3;
Protein Name Sodium/potassium-transporting ATPase subunit alpha
Protein Synonyms/Alias
Gene Name Atpalpha
Gene Synonyms/Alias Na-p;CG5670;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
7-MALRSDYEHGRADSdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated18281928; 16381945; 23193290; 21081558; 19060867; 19366988;
15EHGRADSYRVATVIAdbPTM 3.0;SysPTM 2.018281928; 16381945; 23193290; 19366988
34NRTADGQYKSRRKMPdbPTM 3.0;PHOSIDA;SysPTM 2.0;curated18281928; 16381945; 23193290; 21081558; 19366988; 22817900
70KISPEELYQRFQTHPdbPTM 3.0;SysPTM 2.018281928; 16381945; 23193290; 19366988
692GAELRDVSSDQLDEIPHOSIDA;curated21081558; 22817900
Sequence
(Fasta)
MALRSDYEHG RADSYRVATV IATDDDNRTA DGQYKSRRKM PAKVNKKENL DDLKQELDID 60
FHKISPEELY QRFQTHPENG LSHAKAKENL ERDGPNALTP PKQTPEWVKF CKNLFGGFAM 120
LLWIGAILCF VAYSIQASTS EEPADDNLYL GIVLSAVVIV TGIFSYYQES KSSKIMESFK 180
NMVPQFATVI REGEKLTLRA EDLVLGDVVE VKFGDRIPAD IRIIEARNFK VDNSSLTGES 240
EPQSRGAEFT HENPLETKNL AFFSTNAVEG TAKGVVISCG DHTVMGRIAG LASGLDTGET 300
PIAKEIHHFI HLITGVAVFL GVTFFVIAFI LGYHWLDAVI FLIGIIVANV PEGLLATVTV 360
CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIIEADT 420
TEDQSGVQYD RTSPGFKALS RIATLCNRAE FKGGQDGVPI LKKEVSGDAS EAALLKCMEL 480
ALGDVMNIRK RNKKIAEVPF NSTNKYQVSI HETEDTNDPR YLLVMKGAPE RILERCSTIF 540
INGKEKVLDE EMKEAFNNAY MELGGLGERV LGFCDFMLPS DKYPNGFKFN TDDINFPIDN 600
LRFVGLMSMI DPPRAAVPDA VAKCRSAGIK VIMVTGDHPI TAKAIAKSVG IISEGNETVE 660
DIAQRLNIPV SEVNPREAKA AVVHGAELRD VSSDQLDEIL RYHTEIVFAR TSPQQKLIIV 720
EGCQRMGAIV AVTGDGVNDS PALKKADIGV AMGIAGSDVS KQAADMILLD DNFASIVTGV 780
EEGRLIFDNL KKSIAYTLTS NIPEISPFLA FILCDIPLPL GTVTILCIDL GTDMVPAISL 840
AYEHAEADIM KRPPRDPFND KLVNSRLISM AYGQIGMIQA AAGFFVYFVI MAENGFLPKK 900
LFGIRKMWDS KAVNDLTDSY GQEWTYRDRK TLEYTCHTAF FISIVVVQWA DLIICKTRRN 960
SIFQQGMRNW ALNFGLVFET VLAAFLSYCP GMEKGLRMYP LKLVWWFPAI PFALAIFIYD 1020
ETRRFYLRRN PGGWLEQETY Y 1042
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0406--Ion transport
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0630--Potassium
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0691--RNA editing
KW-0915--Sodium
KW-0739--Sodium transport
KW-0740--Sodium/potassium transport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport

Interpro

IPR006068--ATPase_P-typ_cation-transptr_C
IPR004014--ATPase_P-typ_cation-transptr_N
IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR023298--ATPase_P-typ_TM_dom
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR005775--P-type_ATPase_IIC
IPR001757--P_typ_ATPase

PROSITE

PS00154--ATPASE_E1_E2

Pfam

PF00689--Cation_ATPase_C
PF00690--Cation_ATPase_N
PF00122--E1-E2_ATPase

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0005887--C:integral component of plasma membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005918--C:septate junction
GO:0005890--C:sodium:potassium-exchanging ATPase complex
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005391--F:sodium:potassium-exchanging ATPase activity
GO:0008344--P:adult locomotory behavior
GO:0015991--P:ATP hydrolysis coupled proton transport
GO:0006812--P:cation transport
GO:0030007--P:cellular potassium ion homeostasis
GO:0006883--P:cellular sodium ion homeostasis
GO:0008340--P:determination of adult lifespan
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0007630--P:jump response
GO:0007626--P:locomotory behavior
GO:0050905--P:neuromuscular process
GO:0010107--P:potassium ion import
GO:0008360--P:regulation of cell shape
GO:0035152--P:regulation of tube architecture, open tracheal system
GO:0035158--P:regulation of tube diameter, open tracheal system
GO:0035159--P:regulation of tube length, open tracheal system
GO:0009612--P:response to mechanical stimulus
GO:0009266--P:response to temperature stimulus
GO:0007605--P:sensory perception of sound
GO:0019991--P:septate junction assembly
GO:0036376--P:sodium ion export from cell
GO:0051124--P:synaptic growth at neuromuscular junction
GO:0007268--P:synaptic transmission
GO:0001894--P:tissue homeostasis
GO:0060439--P:trachea morphogenesis