dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005767
Uniprot Accession P13574; STE12_YEAST; D3DL35;
Genbank Protein ID NP_011952.1;
Genbank Nucleotide ID NM_001179214.1;
Protein Name Protein STE12
Protein Synonyms/Alias
Gene Name STE12
Gene Synonyms/Alias YHR084W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids.
Phosphorylation Sites
 dbPAF PTMs: 26 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MKVQITNSRTEEIcurated24961812
26NNENDEVSKATPGEVcurated26040289; 25315811
29NDEVSKATPGEVEESdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 20489023; 19366988;
214QLLQHLDSRRPSSTTUniProt;curated19779198; 22817900
218HLDSRRPSSTTKSDNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900
223RPSSTTKSDNSPPKLdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 21177495; 20489023;
226STTKSDNSPPKLESEdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17330950; 17563356; 18407956; 16381945; 23193290;
232NSPPKLESENFKDNEcurated19823750
261MDDDAPESPSQINDFdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20489023; 12520306; 19366988
286TLELNGLTEETPHDLcurated26040289; 22369663; 20377248
289LNGLTEETPHDLPKNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated17563356; 18407956; 16381945; 23193290; 20489023; 17287358;
376PTFPVPPSSSRQHFMPhosphoGRID 2.0;PhosphoPep 2.0;curated20489023; 19060867; 26040289
377TFPVPPSSSRQHFMTPhosphoPep 2.019060867
378FPVPPSSSRQHFMTNPhosphoPep 2.019060867
400NNKEKLVSPSDPTSYdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 17330950; 17563356; 18407956; 16381945; 23193290;
402KEKLVSPSDPTSYMKcurated22817900; 25315811
451YSNNFQQSYPNGMVPPhosphoGRID 2.012520306
525TYVGRPYTPNYRSTPcurated26040289
585NQYPRRRTVGMKSSQcurated24961812
590RRTVGMKSSQGNVPTPhosphoGRID 2.0;curated20489023; 25315811
Sequence
(Fasta)		MKVQITNSRT EEILKVQANN ENDEVSKATP GEVEESLRLI GDLKFFLATA PVNWQENQII 60
RRYYLNSGQG FVSCVFWNNL YYITGTDIVK CCLYRMQKFG REVVQKKKFE EGIFSDLRNL 120
KCGIDATLEQ PKSEFLSFLF RNMCLKTQKK QKVFFWFSVA HDKLFADALE RDLKRESLNQ 180
PSTTKPVNEP ALSFSYDSSS DKPLYDQLLQ HLDSRRPSST TKSDNSPPKL ESENFKDNEL 240
VTVTNQPLLG VGLMDDDAPE SPSQINDFIP QKLIIEPNTL ELNGLTEETP HDLPKNTAKG 300
RDEEDFPLDY FPVSVEYPTE ENAFDPFPPQ AFTPAAPSMP ISYDNVNERD SMPVNSLLNR 360
YPYQLSVAPT FPVPPSSSRQ HFMTNRDFYS SNNNKEKLVS PSDPTSYMKY DEPVMDFDES 420
RPNENCTNAK SHNSGQQTKQ HQLYSNNFQQ SYPNGMVPGY YPKMPYNPMG GDPLLDQAFY 480
GADDFFFPPE GCDNNMLYPQ TATSWNVLPP QAMQPAPTYV GRPYTPNYRS TPGSAMFPYM 540
QSSNSMQWNT AVSPYSSRAP STTAKNYPPS TFYSQNINQY PRRRTVGMKS SQGNVPTGNK 600
QSVGKSAKIS KPLHIKTSAY QKQYKINLET KARPSAGDED SAHPDKNKEI SMPTPDSNTL 660
VVQSEEGGAH SLEVDTNRRS DKNLPDAT 689
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0589--Pheromone response
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR003120--TF_STE
PROSITE
Pfam

PF02200--STE
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:1990526--C:Ste12p-Dig1p-Dig2p complex
GO:1990527--C:Tec1p-Ste12p-Dig1p complex
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000747--P:conjugation with cellular fusion
GO:0001403--P:invasive growth in response to glucose limitation
GO:0046020--P:negative regulation of transcription from RNA polymerase II promoter by pheromones
GO:0007329--P:positive regulation of transcription from RNA polymerase II promoter by pheromones
GO:0007124--P:pseudohyphal growth
GO:0006351--P:transcription, DNA-templated