dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005755
Uniprot Accession P13496; DCTN1_DROME; B5X0J0; Q8MT52; Q9VUA1;
Genbank Protein ID NP_524061.1;
Genbank Nucleotide ID NM_079337.3;
Protein Name Dynactin subunit 1
Protein Synonyms/Alias 150 kDa dynein-associated polypeptide;DAP-150;DP-150;Protein glued;
Gene Name Gl
Gene Synonyms/Alias CG9206;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Phosphorylation Sites
 dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
85AAPGSRRSIEDVSGAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
110RLSSSRTSLSSSRQSdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;UniProt;curated18327897; 16381945; 23193290; 19060867; 22817900
114SRTSLSSSRQSLLGSdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
117SLSSSRQSLLGSRTQdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
121SRQSLLGSRTQLTTSdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
127GSRTQLTTSLSERTAPhosphoPep 2.019060867
128SRTQLTTSLSERTASPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
135SLSERTASSSSIGPRPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
137SERTASSSSIGPRKScurated22817900
138ERTASSSSIGPRKSLPhosphoPep 2.0;curated19060867; 22817900
144SSIGPRKSLAPQNSKPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
183HASSKRASFVETGFLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 22817900
198EILKPQFTPSQPLRSPhosphoPep 2.0;curated19060867; 22817900
205TPSQPLRSPSFTMPSPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
207SQPLRSPSFTMPSNSPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
370ESAIGNISGGGDSPGcurated22817900
375NISGGGDSPGLSTYEPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
379GGDSPGLSTYEFKQLcurated22817900
1091TGKVQPGSESHSPHNPhosphoPep 2.019060867
1093KVQPGSESHSPHNISPhosphoPep 2.019060867
Sequence
(Fasta)		MSEKNLKVGA RVELTGKDLL GTVAYVGMTS FAVGKWVGVV LDEPKGKNSG SIKGQQYFQC 60
DENCGMFVRP TQLRLLEAAP GSRRSIEDVS GATPTAAQPT KARLSSSRTS LSSSRQSLLG 120
SRTQLTTSLS ERTASSSSIG PRKSLAPQNS KDKESPSTSL AEGAPAASGG NGAASHASSK 180
RASFVETGFL EILKPQFTPS QPLRSPSFTM PSNSGAEDKV ALLEAQKTSA ELQAQLADLT 240
EKLETLKQRR NEDKERLREF DKMKIQFEQL QEFRTKIMGA QASLQKELLR AKQEAKDAIE 300
AKEQHAQEMA DLADNVEMIT LDKEMAEEKA DTLQLELESS KERIEELEVD LELLRSEMQN 360
KAESAIGNIS GGGDSPGLST YEFKQLEQQN IRLKETLVRL RDLSAHDKHD IQKLSKELEM 420
KRSEVTELER TKEKLSAKID ELEAIVADLQ EQVDAALGAE EMVEQLAEKK MELEDKVKLL 480
EEEIAQLEAL EEVHEQLVES NHELELDLRE ELDLANGAKK EVLRERDAAI ETIYDRDQTI 540
VKFRELVQKL NDQLTELRDR NSSNEKESLQ DPSLKMVTET IDYKQMFAES KAYTRAIDVQ 600
LRQIELSQAN EHVQMLTAFM PESFMSRGGD HDSILVILLI SRIVFKCDIV VSQTRERFPP 660
VDAITREAVT QGHAVQQYAF KCRLLHYVHS LQCALHQILY GLNSCQPDTL LRAGSSLPEM 720
VAQEKIVDGI IELLKSNQLD ENSTTDNIEK CVAFFNAMNS VLLAGEQLLN EIQMIRDCVA 780
SLGAACESIL SDTAIAKVII QEAGATSDSV LLIQFLNENM ESVRQQVKLI KRRLPSDQHV 840
IKSGLSQHKV EAMRGLAQNI SRIMSAMHQA TKQSLAAIVS TIESDNAAEH TLPQEKYWAL 900
LTASCERIYE QDDRGPTQNF KTLLAQANSD LQLIAQHLLD KEYDIISAAN NASNQQKSGA 960
HSTPITQRAQ LIKKQLEQKN VLAATLENRE ADVKQLKVAA KMKQNELSEM QIRKDLAEKK 1020
LSVLQNEYEH AVDKWKQKYE ETSLQLQLKE KEFEETMDHL QSDIDALESE KSDLRDKLKL 1080
NSTTGKVQPG SESHSPHNIS LSGNTSTAPG ISNVSYSAPA GTAPVVAEEV ELLKNAFNQE 1140
RNQRLRLQAQ DMRAKLSQFE PLHVPQPQDQ RITALESELT RMKHAWVLSL LQVRSQDSVN 1200
SGTRIDAVAL QRRNQPVPLK GEISSKASQL ASDILTEYLQ RKPHRATHGQ FASFPTVDVK 1260
RVLQI 1266
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0243--Dynein
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR027663--DCTN1
IPR022157--Dynactin
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
Pfam

PF01302--CAP_GLY
PF12455--Dynactin
Gene Ontology

GO:0005818--C:aster
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005869--C:dynactin complex
GO:0030286--C:dynein complex
GO:0000776--C:kinetochore
GO:0005828--C:kinetochore microtubule
GO:0035371--C:microtubule plus-end
GO:0030496--C:midbody
GO:0005876--C:spindle microtubule
GO:0031616--C:spindle pole centrosome
GO:0045502--F:dynein binding
GO:0003774--F:motor activity
GO:0048675--P:axon extension
GO:0001709--P:cell fate determination
GO:0007349--P:cellularization
GO:0051642--P:centrosome localization
GO:0051299--P:centrosome separation
GO:0001751--P:compound eye photoreceptor cell differentiation
GO:0042051--P:compound eye photoreceptor development
GO:0045198--P:establishment of epithelial cell apical/basal polarity
GO:0001754--P:eye photoreceptor cell differentiation
GO:0006886--P:intracellular protein transport
GO:0051383--P:kinetochore organization
GO:0035011--P:melanotic encapsulation of foreign target
GO:0007018--P:microtubule-based movement
GO:0047497--P:mitochondrion transport along microtubule
GO:0007067--P:mitotic nuclear division
GO:0051256--P:mitotic spindle midzone assembly
GO:0007052--P:mitotic spindle organization
GO:0051028--P:mRNA transport
GO:0022008--P:neurogenesis
GO:0048477--P:oogenesis
GO:0034501--P:protein localization to kinetochore
GO:0008090--P:retrograde axon cargo transport
GO:0048491--P:retrograde synaptic vesicle transport
GO:0042052--P:rhabdomere development
GO:0016330--P:second mitotic wave involved in compound eye morphogenesis
GO:0051225--P:spindle assembly