| Tag |
Content |
| dbPAF ID |
dbPAF-0005740 |
| Uniprot Accession |
P13393; TBP_YEAST; D3DM55;
|
| Genbank Protein ID |
NP_011075.3;
|
| Genbank Nucleotide ID |
NM_001179038.3;
|
| Protein Name |
TATA-box-binding protein |
| Protein Synonyms/Alias |
TATA sequence-binding protein;TBP;TATA-binding factor;TATA-box factor;Transcription factor D;Transcription initiation factor TFIID TBP subunit; |
| Gene Name |
SPT15 |
| Gene Synonyms/Alias |
BTF1;TBP1;YER148W; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.Functional Description
General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MADEERLKEF KEANKIVFDP NTRQVWENQN RDGTKPATTF QSEEDIKRAA PESEKDTSAT 60
SGIVPTLQNI VATVTLGCRL DLKTVALHAR NAEYNPKRFA AVIMRIREPK TTALIFASGK 120
MVVTGAKSED DSKLASRKYA RIIQKIGFAA KFTDFKIQNI VGSCDVKFPI RLEGLAFSHG 180
TFSSYEPELF PGLIYRMVKP KIVLLIFVSG KIVLTGAKQR EEIYQAFEAI YPVLSEFRKM 240
241Fasta Sequence
>P13393|SPT15|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEEDIKRAAPESEKDTSATSGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
|
| Interpro |
IPR012295--Beta2_adaptin/TBP_C_dom
IPR000814--TBP
IPR030491--TBP_CS
|
| PROSITE |
PS00351--TFIID
|
| Pfam |
PF00352--TBP
|
| Gene Ontology |
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005669--C:transcription factor TFIID complex
GO:0000126--C:transcription factor TFIIIB complex
GO:0003682--F:chromatin binding
GO:0008301--F:DNA binding, bending
GO:0001179--F:RNA polymerase I transcription factor binding
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0001016--F:RNA polymerase III regulatory region DNA binding
GO:0001026--F:TFIIIB-type transcription factor activity
GO:0001186--F:transcription factor activity, RNA polymerase I transcription factor recruiting
GO:0001075--F:transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
GO:0006356--P:regulation of transcription from RNA polymerase I promoter
GO:0006359--P:regulation of transcription from RNA polymerase III promoter
GO:0051123--P:RNA polymerase II transcriptional preinitiation complex assembly
GO:0070898--P:RNA polymerase III transcriptional preinitiation complex assembly
GO:0042790--P:transcription of nuclear large rRNA transcript from RNA polymerase I promoter
GO:0070893--P:transposon integration
|
