dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005730
Uniprot Accession P13298; PYRE_YEAST; D6W0H8;
Genbank Protein ID NP_013601.1;
Genbank Nucleotide ID NM_001182468.1;
Protein Name Orotate phosphoribosyltransferase 1
Protein Synonyms/Alias
Gene Name URA5
Gene Synonyms/Alias PYR5;YML106W;YM8339.13;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
213RITAEEKSKIEQYLQPhosphoGRID 2.0;UniProt;curated19779198; 22817900
225YLQTYGASA------PhosphoGRID 2.0;UniProt;curated19779198; 24961812
Sequence
(Fasta)		MPIMLEDYQK NFLELAIECQ ALRFGSFKLK SGRESPYFFN LGLFNTGKLL SNLATAYAIA 60
IIQSDLKFDV IFGPAYKGIP LAAIVCVKLA EIGGSKFQNI QYAFNRKEAK DHGEGGIIVG 120
SALENKRILI IDDVMTAGTA INEAFEIISN AKGQVVGSII ALDRQEVVST DDKEGLSATQ 180
TVSKKYGIPV LSIVSLIHII TYLEGRITAE EKSKIEQYLQ TYGASA 227
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0328--Glycosyltransferase
KW-0597--Phosphoprotein
KW-0665--Pyrimidine biosynthesis
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR023031--OPRT
IPR004467--Or_phspho_trans_dom
IPR000836--PRibTrfase_dom
IPR029057--PRTase-like
PROSITE

PS00103--PUR_PYR_PR_TRANSFER
Pfam

PF00156--Pribosyltran
Gene Ontology

GO:0004588--F:orotate phosphoribosyltransferase activity
GO:0006207--P:'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205--P:'de novo' UMP biosynthetic process
GO:0046132--P:pyrimidine ribonucleoside biosynthetic process