| Tag |
Content |
| dbPAF ID |
dbPAF-0005720 |
| Uniprot Accession |
P13217; PIPA_DROME; A4V3Y2; Q59E70; Q86P93; Q9U4G4; Q9W4K9;
|
| Genbank Protein ID |
NP_001014720.1; NP_001014721.1; NP_001162661.1; NP_001284860.1; NP_525069.2; NP_726925.1;
|
| Genbank Nucleotide ID |
NM_001014720.2; NM_001014721.3; NM_001169190.2; NM_001297931.1; NM_080330.4; NM_167008.2;
|
| Protein Name |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
| Protein Synonyms/Alias |
No receptor potential A protein;Phosphoinositide phospholipase C; |
| Gene Name |
norpA |
| Gene Synonyms/Alias |
CG3620; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential component of the phototransduction pathway.Functional Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential component of the phototransduction pathway. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MTKKYEFDWI IPVPPELTTG CVFDRWFENE KETKENDFER DALFKVDEYG FFLYWKSEGR 60
DGDVIELCQV SDIRAGGTPK DPKILDKVTK KNGTNIPELD KRSLTICSNT DYINITYHHV 120
ICPDAATAKS WQKNLRLITH NNRATNVCPR VNLMKHWMRL SYCVEKSGKI PVKTLAKTFA 180
SGKTEKLVYT CIKDAGLPDD KNATMTKEQF TFDKFYALYH KVCPRNDIEE LFTSITKGKQ 240
DFISLEQFIQ FMNDKQRDPR MNEILYPLYE EKRCTEIIND YELDEEKKKN VQMSLDGFKR 300
YLMSDENAPV FLDRLDFYME MDQPLAHYYI NSSHNTYLSG RQIGGKSSVE MYRQTLLAGC 360
RCVELDCWNG KGEDEEPIVT HGHAYCTEIL FKDCIQAIAD CAFVSSEYPV ILSFENHCNR 420
AQQYKLAKYC DDFFGDLLLK EPLPDHPLDP GLPLPPPCKL KRKILIKNKR MKPEVEKVEL 480
ELWLKGELKT DDDPEEDASA GKPPEAAAAP APAPEAAAAA EGAAEGGGGA EAEAAAANYS 540
GSTTNVHPWL SSMVNYAQPI KFQGFDKAIE KNIAHNMSSF AESAGMNYLK QSSIDFVNYN 600
KRQMSRIYPK GTRADSSNYM PQVFWNAGCQ MVSLNFQSSD LPMQLNQGKF EYNGGCGYLL 660
KPDFMRRADK DFDPFADAPV DGVIAAQCSV KVIAGQFLSD KKVGTYVEVD MFGLPSDTVK 720
KEFRTRLVAN NGLNPVYNED PFVFRKVVLP DLAVLRFGVY EESGKILGQR ILPLDGLQAG 780
YRHVSLRTEA NFPMSLPMLF VNIELKIYVP DGFEDFMAML SDPRGFAGAA KQQNEQMKAL 840
GIEEQSGGAA RDAGKAKEEE KKEPPLVFEP VTLESLRQEK GFQKVGKKQI KELDTLRKKH 900
AKERTSVQKT QNAAIDKLIK GKSKDDIRND ANIKNSINDQ TKQWTDMIAR HRKEEWDMLR 960
QHVQDSQDAM KALMLTVQAA QIKQLEDRHA RDIKDLNAKQ AKMSADTAKE VQNDKTLKTK 1020
NEKDRRLREK RQNNVKRFME EKKQIGVKQG RAMEKLKLAH SKQIEEFSTD VQKLMDMYKI 1080
EEEAYKTQGK TEFYA
1096Fasta Sequence
>P13217|norpA|Drosophila melanogaster(Fruit fly)
MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIRNDANIKNSINDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKLMDMYKIEEEAYKTQGKTEFYA
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0716--Sensory transduction
KW-0807--Transducer
KW-0844--Vision
|
| Interpro |
IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH/PTB_dom
IPR001192--PI-PLC_fam
IPR016280--PLC-beta
IPR009535--PLC-beta_CS
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR015359--PLC_EF-hand-like
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
|
| PROSITE |
PS50004--C2
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
|
| Pfam |
PF00168--C2
PF06631--DUF1154
PF09279--EF-hand_like
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0016027--C:inaD signaling complex
GO:0005622--C:intracellular
GO:0016028--C:rhabdomere
GO:0005509--F:calcium ion binding
GO:0005096--F:GTPase activator activity
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004629--F:phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0008344--P:adult locomotory behavior
GO:0019722--P:calcium-mediated signaling
GO:0016059--P:deactivation of rhodopsin mediated signaling
GO:0001580--P:detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006651--P:diacylglycerol biosynthetic process
GO:0009649--P:entrainment of circadian clock
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0008377--P:light-induced release of internally sequestered calcium ion
GO:0016042--P:lipid catabolic process
GO:0002385--P:mucosal immune response
GO:0046673--P:negative regulation of compound eye retinal cell programmed cell death
GO:0046488--P:phosphatidylinositol metabolic process
GO:0008654--P:phospholipid biosynthetic process
GO:0006644--P:phospholipid metabolic process
GO:0045494--P:photoreceptor cell maintenance
GO:0007602--P:phototransduction
GO:2000370--P:positive regulation of clathrin-mediated endocytosis
GO:0051482--P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0043547--P:positive regulation of GTPase activity
GO:0016056--P:rhodopsin mediated signaling pathway
GO:0043052--P:thermotaxis
GO:0007601--P:visual perception
|
