dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005717
Uniprot Accession P13186; KIN2_YEAST; D6VY96; Q12384;
Genbank Protein ID NP_013197.1;
Genbank Nucleotide ID NM_001181983.1;
Protein Name Serine/threonine-protein kinase KIN2
Protein Synonyms/Alias
Gene Name KIN2
Gene Synonyms/Alias YLR096W;L8004.3;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.
Phosphorylation Sites
 dbPAF PTMs: 42 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MPNPNTADYLVNPPHOSIDA;curated21081558; 19795423
17LVNPNFRTSKGGSLScurated22817900; 19547744
18VNPNFRTSKGGSLSPPHOSIDA;curated21081558; 19795423
22FRTSKGGSLSPTPEAPhosphoGRID 2.0;PhosphoPep 2.0;UniProt;curated20489023; 21126336; 19779198; 19060867; 26040289; 22817900;
24TSKGGSLSPTPEAFNdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20489023; 19779198; 19366988;
26KGGSLSPTPEAFNDTcurated25315811
146HKQHSLPSPKNESEIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17287358; 17563356; 16381945; 23193290; 20489023; 19823750;
151LPSPKNESEILERQKdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20489023; 21126336; 19823750;
549KVALNNNSPDIMTKMdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 21177495; 20489023;
608TIPEQAHTSPTSRKSPhosphoGRID 2.0;curated21177495; 19823750; 19547744
609IPEQAHTSPTSRKSSdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 20489023; 19779198;
611EQAHTSPTSRKSSDIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19060867; 19366988
612QAHTSPTSRKSSDIHdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19060867; 19366988; 26040406;
615TSPTSRKSSDIHTELcurated22369663; 24961812; 25315811
616SPTSRKSSDIHTELNPhosphoGRID 2.0;curated19779198; 26040289; 22817900
628ELNGVLKSTPVPVSGcurated25315811
634KSTPVPVSGEYQQRScurated25315811
641SGEYQQRSASPVVGEdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 21177495; 20489023;
643EYQQRSASPVVGEHQdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 21177495; 20489023;
663GGIFRRISQSGQSQHdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 20702584; 19060867; 19366988;
Sequence
(Fasta)		MPNPNTADYL VNPNFRTSKG GSLSPTPEAF NDTRVAAPAT LRMMGKQSGP RNDQQQAPLM 60
PPADIKQGKE QAAQRQNDAS RPNGAVELRQ FHRRSLGDWE FLETVGAGSM GKVKLVKHRQ 120
TKEICVIKIV NRASKAYLHK QHSLPSPKNE SEILERQKRL EKEIARDKRT VREASLGQIL 180
YHPHICRLFE MCTMSNHFYM LFEYVSGGQL LDYIIQHGSL KEHHARKFAR GIASALQYLH 240
ANNIVHRDLK IENIMISSSG EIKIIDFGLS NIFDYRKQLH TFCGSLYFAA PELLKAQPYT 300
GPEVDIWSFG IVLYVLVCGK VPFDDENSSI LHEKIKKGKV DYPSHLSIEV ISLLTRMIVV 360
DPLRRATLKN VVEHPWMNRG YDFKAPSYVP NRVPLTPEMI DSQVLKEMYR LEFIDDIEDT 420
RRSLIRLVTE KEYIQLSQEY WDKLSNAKGL SSSLNNNYLN STAQQTLIQN HITSNPSQSG 480
YNEPDSNFED PTLAYHPLLS IYHLVSEMVA RKLAKLQRRQ ALALQAQAQQ RQQQQQVALG 540
TKVALNNNSP DIMTKMRSPQ KEVVPNPGIF QVPAIGTSGT SNNTNTSNKP PLHVMVPPKL 600
TIPEQAHTSP TSRKSSDIHT ELNGVLKSTP VPVSGEYQQR SASPVVGEHQ EKNTIGGIFR 660
RISQSGQSQH PTRQQEPLPE REPPTYMSKS NEISIKVPKS HSRTISDYIP SARRYPSYVP 720
NSVDVKQKPA KNTTIAPPIR SVSQKQNSDL PALPQNAELI VQKQRQKLLQ ENLDKLQIND 780
NDNNNVNAVV DGINNDNSDH YLSVPKGRKL HPSARAKSVG HARRESLKFT RPPIPAALPP 840
SDMTNDNGFL GEANKERYNP VSSNFSTVPE DSTTYSNDTN NRLTSVYSQE LTEKQILEEA 900
SKAPPGSMPS IDYPKSMFLK GFFSVQTTSS KPLPIVRHNI ISVLTRMNID FKEVKGGFIC 960
VQQRPSIETA AVPVITTTGV GLDSGKAMDL QNSLDSQLSS SYHSTASSAS RNSSIKRQGS 1020
YKRGQNNIPL TPLATNTHQR NSSIPMSPNY GNQSNGTSGE LSSMSLDYVQ QQDDILTTSR 1080
AQNINNVNGQ TEQTNTSGIK ERPPIKFEIH IVKVRIVGLA GVHFKKVSGN TWLYKELASY 1140
ILKELNL 1148
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0268--Exocytosis
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF02149--KA1
PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0006887--P:exocytosis
GO:0035556--P:intracellular signal transduction
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation