| Tag |
Content |
| dbPAF ID |
dbPAF-0005709 |
| Uniprot Accession |
P13098; ESM8_DROME; Q0IGQ3; Q2XYK0; Q5S426; Q5S462; Q5S474; Q5S4H0; Q5S4I2; Q9VBI5;
|
| Genbank Protein ID |
NP_524513.1;
|
| Genbank Nucleotide ID |
NM_079789.3;
|
| Protein Name |
Enhancer of split m8 protein |
| Protein Synonyms/Alias |
|
| Gene Name |
E(spl) |
| Gene Synonyms/Alias |
m8;CG8365; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'.Functional Description
Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MEYTTKTQIY QKVKKPMLER QRRARMNKCL DNLKTLVAEL RGDDGILRMD KAEMLESAVI 60
FMRQQKTPKK VAQEEQSLPL DSFKNGYMNA VNEVSRVMAS TPGMSVDLGK SVMTHLGRVY 120
KNLQQFHEAQ SAADFIQNSM DCSSMDKAPL SPASSGYHSD CDSPAPSPQP MQQPLWRPW
180
Fasta Sequence
>P13098|E(spl)|Drosophila melanogaster(Fruit fly)
MEYTTKTQIYQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDGILRMDKAEMLESAVIFMRQQKTPKKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQFHEAQSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR011598--bHLH_dom
IPR003650--Orange_dom
|
| PROSITE |
PS50888--BHLH
PS51054--ORANGE
|
| Pfam |
PF07527--Hairy_orange
PF00010--HLH
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0048749--P:compound eye development
GO:0048813--P:dendrite morphogenesis
GO:0007398--P:ectoderm development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0008587--P:imaginal disc-derived wing margin morphogenesis
GO:0007498--P:mesoderm development
GO:0010629--P:negative regulation of gene expression
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048666--P:neuron development
GO:0007219--P:Notch signaling pathway
GO:0007422--P:peripheral nervous system development
GO:0045468--P:regulation of R8 cell spacing in compound eye
GO:0016360--P:sensory organ precursor cell fate determination
GO:0006351--P:transcription, DNA-templated
|
