| Tag |
Content |
| dbPAF ID |
dbPAF-0005704 |
| Uniprot Accession |
P13060; EF2_DROME; A0A023GPJ5; Q9I7H2; Q9V9R0;
|
| Genbank Protein ID |
NP_525105.2; NP_724357.2; NP_724358.2;
|
| Genbank Nucleotide ID |
NM_080366.3; NM_165394.3; NM_165395.2;
|
| Protein Name |
Elongation factor 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
EF2 |
| Gene Synonyms/Alias |
Ef2b;CG2238; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).Functional Description
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MVNFTVDEIR GLMDKKRNIR NMSVIAHVDH GKSTLTDSLV SKAGIIAGAK AGETRFTDTR 60
KDEQERCITI KSTAISMYFE VEEKDLVFIT HPDQREKECK GFLINLIDSP GHVDFSSEVT 120
AALRVTDGAL VVVDCVSGVC VQTETVLRQA IAERIKPILF MNKMDRALLE LQLDAEELYQ 180
TFQRIVENVN VIIATYNDDG GPMGEVRVDP SKGSVGFGSG LHGWAFTLKQ FSEMYSEKFK 240
IDVVKLMNRL WGENFFNAKT KKWQKQKEAD NKRSFCMYIL DPIYKVFDAI MNYKKEEIGT 300
LLEKIGVTLK HEDKDKDGKA LLKTVMRTWL PAGEALLQMI AIHLPSPVVA QKYRMEMLYE 360
GPHDDEAAIA VKSCDPDGPL MMYISKMVPT SDKGRFYAFG RVFAGKVATG QKCRIMGPNY 420
TPGKKEDLYE KAIQRTILMM GRYVEAIEDV PSGNICGLVG VDQFLVKTGT ITTFKDAHNM 480
KVMKFSVSPV VRVAVEPKNP ADLPKLVEGL KRLAKSDPMV QCIIEESGEH IIAGAGELHL 540
EICLKDLEED HACIPLKKSD PVVSYRETVS EESDQMCLSK SPNKHNRLLM KALPMPDGLP 600
EDIDNGDVSA KDEFKARARY LSEKYDYDVT EARKIWCFGP DGTGPNFILD CTKSVQYLNE 660
IKDSVVAGFQ WASKEGILAD ENLRGVRFNI YDVTLHADAI HRGGGQIIPT TRRCLYAAAI 720
TAKPRLMEPV YLCEIQCPEV AVGGIYGVLN RRRGHVFEEN QVVGTPMFVV KAYLPVNESF 780
GFTADLRSNT GGQAFPQCVF DHWQVLPGDP SEPSSKPYAI VQDTRKRKGL KEGLPDLSQY 840
LDKL
845Fasta Sequence
>P13060|EF2|Drosophila melanogaster(Fruit fly)
MVNFTVDEIRGLMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIKSTAISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPILFMNKMDRALLELQLDAEELYQTFQRIVENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKWQKQKEADNKRSFCMYILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLKHEDKDKDGKALLKTVMRTWLPAGEALLQMIAIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDLYEKAIQRTILMMGRYVEAIEDVPSGNICGLVGVDQFLVKTGTITTFKDAHNMKVMKFSVSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLLMKALPMPDGLPEDIDNGDVSAKDEFKARARYLSEKYDYDVTEARKIWCFGPDGTGPNFILDCTKSVQYLNEIKDSVVAGFQWASKEGILADENLRGVRFNIYDVTLHADAIHRGGGQIIPTTRRCLYAAAITAKPRLMEPVYLCEIQCPEVAVGGIYGVLNRRRGHVFEENQVVGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPSEPSSKPYAIVQDTRKRKGLKEGLPDLSQYLDKL
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0251--Elongation factor
KW-0342--GTP-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
|
| Interpro |
IPR009022--EFG_III-V
IPR000640--EFG_V
IPR031157--G_TR_CS
IPR027417--P-loop_NTPase
IPR020568--Ribosomal_S5_D2-typ_fold
IPR014721--Ribosomal_S5_D2-typ_fold_subgr
IPR005225--Small_GTP-bd_dom
IPR000795--TF_GTP-bd_dom
IPR009000--Transl_B-barrel
IPR005517--Transl_elong_EFG/EF2_IV
IPR004161--Transl_elong_EFTu/EF1A_2
|
| PROSITE |
PS00301--G_TR_1
PS51722--G_TR_2
|
| Pfam |
PF00679--EFG_C
PF14492--EFG_II
PF03764--EFG_IV
PF03144--GTP_EFTU_D2
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005875--C:microtubule associated complex
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0003746--F:translation elongation factor activity
GO:0000022--P:mitotic spindle elongation
GO:0007052--P:mitotic spindle organization
GO:0006414--P:translational elongation
|
