| Tag |
Content |
| dbPAF ID |
dbPAF-0005697 |
| Uniprot Accession |
P13002; ELF1_DROME; A0JQ61; Q6NN37; Q86PE1; Q8MMA8; Q8MMB0; Q8MMB1; Q960H2; Q9TYG4; Q9V889; Q9V890; Q9V891;
|
| Genbank Protein ID |
NP_001286551.1; NP_476842.2; NP_476843.2; NP_476844.2; NP_476845.2; NP_725725.1;
|
| Genbank Nucleotide ID |
NM_001299622.1; NM_057494.4; NM_057495.4; NM_057496.5; NM_057497.4; NM_166252.3;
|
| Protein Name |
Protein grainyhead |
| Protein Synonyms/Alias |
DNA-binding protein ELF-1;Element I-binding activity;Protein grainy-head;Transcription factor NTF-1; |
| Gene Name |
grh |
| Gene Synonyms/Alias |
elf1;CG5058; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Binds a CNS-specific regulatory element of the Dopa decarboxylase (Ddc) gene. Also interacts with sequences adjacent to other transcription units, including Ultrabithorax (Ubx) and engrailed (en). Activity in vivo may be required only at high levels transiently to activate the expression of Ddc in the CNS.Functional Description
Binds a CNS-specific regulatory element of the Dopa decarboxylase (Ddc) gene. Also interacts with sequences adjacent to other transcription units, including Ultrabithorax (Ubx) and engrailed (en). Activity in vivo may be required only at high levels transiently to activate the expression of Ddc in the CNS. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 1179 | SPDLKGASPFLLHGQ | SysPTM 2.0 | 18327897; 19366988 |
|
Sequence
(Fasta) | MSTSTATTSV ITSNELSLSG HAHGHGHAHQ LHQHTHSRLG VGVGVGILSD ASLSPIQQGS 60
GGHSGGGNTN SSPLAPNGVP LLTTMHRSPD SPQPELATMT NVNVLDLHTD NSKLYDKEAV 120
FIYETPKVVM PADGGGGNNS DEGHAIDARI AAQMGNQAQQ QQQQQQQTEH QPLAKIEFDE 180
NQIIRVVGPN GEQQQIISRE IINGEHHILS RNEAGEHILT RIVSDPSKLM PNDNAVATAM 240
YNQAQKMNND HGQAVYQTSP LPLDASVLHY SGGNDSNVIK TEADIYEDHK KHAAAAAAAA 300
GGGSIIYTTS DPNGVNVKQL PHLTVPQKLD PDLYQADKHI DLIYNDGSKT VIYSTTDQKS 360
LEIYSGGDIG SLVSDGQVVV QAGLPYATTT GAGGQPVYIV ADGALPAGVE EHLQSGKLNG 420
QTTPIDVSGL SQNEIQGFLL GSHPSSSATV STTGVVSTTT ISHHQQQQQQ QQQQQQQQQQ 480
QHQQQQQHPG DIVSAAGVGS TGSIVSSAAQ QQQQQQLISI KREPEDLRKD PKNGNIAGAA 540
TANGPGSVIT QKILHVDAPT ASEADRPSTP SSSINSTENT ESDSQSVSGS ESGSPGARTT 600
ATLEMYATTG GTQIYLQTSH PSTASGAGGG AGPAGAAGGG GVSMQAQSPS PGPYITANDY 660
GMYTASRLPP GPPPTSTTTF IAEPSYYREY FAPDGQGGYV PASTRSLYGD VDVSVSQPGG 720
VVTYEGRFAG SVPPPATTTV LTSVHHHQQQ QQQQQQHQQQ QQQQQHHQQQ QHHSQDGKSN 780
GGATPLYAKA ITAAGLTVDL PSPDSGIGTD AITPRDQTNI QQSFDYTELC QPGTLIDANG 840
SIPVSVNSIQ QRTAVHGSQN SPTTSLVDTS TNGSTRSRPW HDFGRQNDAD KIQIPKIFTN 900
VGFRYHLESP ISSSQRREDD RITYINKGQF YGITLEYVHD AEKPIKNTTV KSVIMLMFRE 960
EKSPEDEIKA WQFWHSRQHS VKQRILDADT KNSVGLVGCI EEVSHNAIAV YWNPLESSAK 1020
INIAVQCLST DFSSQKGVKG LPLHVQIDTF EDPRDTAVFH RGYCQIKVFC DKGAERKTRD 1080
EERRAAKRKM TATGRKKLDE LYHPVTDRSE FYGMQDFAKP PVLFSPAEDM EKVGQLGIGA 1140
ATGMTFNPLS NGNSNSNSHS SLQSFYGHET DSPDLKGASP FLLHGQKVAT PTLKFHNHFP 1200
PDMQTDKKDH ILDQNMLTST PLTDFGPPMK RGRMTPPTSE RVMLYVRQEN EEVYTPLHVV 1260
PPTTIGLLNA IENKYKISTT SINNIYRTNK KGITAKIDDD MISFYCNEDI FLLEVQQIED 1320
DLYDVTLTEL PNQ
1334Fasta Sequence
>P13002|grh|Drosophila melanogaster(Fruit fly)
MSTSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAVFIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDENQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAMYNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAAGGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKSLEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQSGKLNGQTTPIDVSGLSQNEIQGFLLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGDIVSAAGVGSTGSIVSSAAQQQQQQQLISIKREPEDLRKDPKNGNIAGAATANGPGSVITQKILHVDAPTASEADRPSTPSSSINSTENTESDSQSVSGSESGSPGARTTATLEMYATTGGTQIYLQTSHPSTASGAGGGAGPAGAAGGGGVSMQAQSPSPGPYITANDYGMYTASRLPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTRSLYGDVDVSVSQPGGVVTYEGRFAGSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGATPLYAKAITAAGLTVDLPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPVSVNSIQQRTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDADKIQIPKIFTNVGFRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFEDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTELPNQ
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR007604--CP2
|
| PROSITE |
|
| Pfam |
PF04516--CP2
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042803--F:protein homodimerization activity
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0040003--P:chitin-based cuticle development
GO:0008362--P:chitin-based embryonic cuticle biosynthetic process
GO:0003382--P:epithelial cell morphogenesis
GO:0007402--P:ganglion mother cell fate determination
GO:0061024--P:membrane organization
GO:0007399--P:nervous system development
GO:0007424--P:open tracheal system development
GO:0007009--P:plasma membrane organization
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007428--P:primary branching, open tracheal system
GO:0007464--P:R3/R4 cell fate commitment
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0035152--P:regulation of tube architecture, open tracheal system
GO:0035159--P:regulation of tube length, open tracheal system
GO:0061041--P:regulation of wound healing
GO:0042052--P:rhabdomere development
GO:0007426--P:tracheal outgrowth, open tracheal system
GO:0006351--P:transcription, DNA-templated
GO:0007419--P:ventral cord development
|
