| Tag |
Content |
| dbPAF ID |
dbPAF-0005648 |
| Uniprot Accession |
P12689; REV1_YEAST; D6W341; Q12323;
|
| Genbank Protein ID |
NP_014991.1;
|
| Genbank Nucleotide ID |
NM_001183766.1;
|
| Protein Name |
DNA repair protein REV1 |
| Protein Synonyms/Alias |
Reversionless protein 1; |
| Gene Name |
REV1 |
| Gene Synonyms/Alias |
YOR346W;O6339; |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast) |
| NCBI Taxa ID |
559292 |
Functional Description
(View all) |
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.Functional Description
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis. |
Phosphorylation Sites
|
dbPAF PTMs: 9 |
Sequence
(Fasta) | MGEHGGLVDL LDSDLEYSIN RETPDKNNCL SQQSVNDSHL TAKTGGLNAR SFLSTLSDDS 60
LIEYVNQLSQ TNKNNSNPTA GTLRFTTKNI SCDELHADLG GGEDSPIARS VIEIQESDSN 120
GDDVKKNTVY TREAYFHEKA HGQTLQDQIL KDQYKDQISS QSSKIFKNCV IYINGYTKPG 180
RLQLHEMIVL HGGKFLHYLS SKKTVTHIVA SNLPLKKRIE FANYKVVSPD WIVDSVKEAR 240
LLPWQNYSLT SKLDEQQKKL DNCKTVNSIP LPSETSLHKG SKCVGSALLP VEQQSPVNLN 300
NLEAKRIVAC DDPDFLTSYF AHSRLHHLSA WKANLKDKFL NENIHKYTKI TDKDTYIIFH 360
IDFDCFFATV AYLCRSSSFS ACDFKRDPIV VCHGTKNSDI ASCNYVARSY GIKNGMWVSQ 420
AEKMLPNGIK LISLPYTFEQ FQLKSEAFYS TLKRLNIFNL ILPISIDEAV CVRIIPDNIH 480
NTNTLNARLC EEIRQEIFQG TNGCTVSIGC SDSLVLARLA LKMAKPNGYN ITFKSNLSEE 540
FWSSFKLDDL PGVGHSTLSR LESTFDSPHS LNDLRKRYTL DALKASVGSK LGMKIHLALQ 600
GQDDEESLKI LYDPKEVLQR KSLSIDINWG IRFKNITQVD LFIERGCQYL LEKLNEINKT 660
TSQITLKLMR RCKDAPIEPP KYMGMGRCDS FSRSSRLGIP TNEFGIIATE MKSLYRTLGC 720
PPMELRGLAL QFNKLVDVGP DNNQLKLRLP FKTIVTNRAF EALPEDVKND INNEFEKRNY 780
KRKESGLTSN SLSSKKKGFA ISRLEVNDLP STMEEQFMNE LPTQIRAEVR HDLRIQKKIQ 840
QTKLGNLQEK IKRREESLQN EKNHFMGQNS IFQPIKFQNL TRFKKICQLV KQWVAETLGD 900
GGPHEKDVKL FVKYLIKLCD SNRVHLVLHL SNLISRELNL CAFLNQDHSG FQTWERILLN 960
DIIPLLNRNK HTYQTVRKLD MDFEV
986Fasta Sequence
>P12689|REV1|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
MGEHGGLVDLLDSDLEYSINRETPDKNNCLSQQSVNDSHLTAKTGGLNARSFLSTLSDDSLIEYVNQLSQTNKNNSNPTAGTLRFTTKNISCDELHADLGGGEDSPIARSVIEIQESDSNGDDVKKNTVYTREAYFHEKAHGQTLQDQILKDQYKDQISSQSSKIFKNCVIYINGYTKPGRLQLHEMIVLHGGKFLHYLSSKKTVTHIVASNLPLKKRIEFANYKVVSPDWIVDSVKEARLLPWQNYSLTSKLDEQQKKLDNCKTVNSIPLPSETSLHKGSKCVGSALLPVEQQSPVNLNNLEAKRIVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTYIIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYVARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLNIFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTVSIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHSTLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEESLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNEINKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGIIATEMKSLYRTLGCPPMELRGLALQFNKLVDVGPDNNQLKLRLPFKTIVTNRAFEALPEDVKNDINNEFEKRNYKRKESGLTSNSLSSKKKGFAISRLEVNDLPSTMEEQFMNELPTQIRAEVRHDLRIQKKIQQTKLGNLQEKIKRREESLQNEKNHFMGQNSIFQPIKFQNLTRFKKICQLVKQWVAETLGDGGPHEKDVKLFVKYLIKLCDSNRVHLVLHLSNLISRELNLCAFLNQDHSGFQTWERILLNDIIPLLNRNKHTYQTVRKLDMDFEV
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR001357--BRCT_dom
IPR017961--DNA_pol_Y-fam_little_finger
IPR012112--REV1
IPR001126--UmuC
|
| PROSITE |
PS50172--BRCT
PS50173--UMUC
|
| Pfam |
PF00533--BRCT
PF00817--IMS
PF11799--IMS_C
|
| Gene Ontology |
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0003684--F:damaged DNA binding
GO:0017125--F:deoxycytidyl transferase activity
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0000287--F:magnesium ion binding
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
|
