dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005643
Uniprot Accession P12684; HMDH2_YEAST; D6VZ84; E9P8X3;
Genbank Protein ID NP_013555.1;
Genbank Nucleotide ID NM_001182338.1;
Protein Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Protein Synonyms/Alias
Gene Name HMG2
Gene Synonyms/Alias YLR450W;L9324.2;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
548VVQQKSATIEFSETRdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 20377248
556IEFSETRSMPASSGLPhosphoGRID 2.021126336
565PASSGLETPVTAKDIdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19060867; 19366988;
568SGLETPVTAKDIIISdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
650LVRRKALSTLAESPIPhosphoGRID 2.021126336
655ALSTLAESPILVSEKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 24961812
Sequence
(Fasta)		MSLPLKTIVH LVKPFACTAR FSARYPIHVI VVAVLLSAAA YLSVTQSYLN EWKLDSNQYS 60
TYLSIKPDEL FEKCTHYYRS PVSDTWKLLS SKEAADIYTP FHYYLSTISF QSKDNSTTLP 120
SLDDVIYSVD HTRYLLSEEP KIPTELVSEN GTKWRLRNNS NFILDLHNIY RNMVKQFSNK 180
TSEFDQFDLF IILAAYLTLF YTLCCLFNDM RKIGSKFWLS FSALSNSACA LYLSLYTTHS 240
LLKKPASLLS LVIGLPFIVV IIGFKHKVRL AAFSLQKFHR ISIDKKITVS NIIYEAMFQE 300
GAYLIRDYLF YISSFIGCAI YARHLPGLVN FCILSTFMLV FDLLLSATFY SAILSMKLEI 360
NIIHRSTVIR QTLEEDGVVP TTADIIYKDE TASEPHFLRS NVAIILGKAS VIGLLLLINL 420
YVFTDKLNAT ILNTVYFDST IYSLPNFINY KDIGNLSNQV IISVLPKQYY TPLKKYHQIE 480
DSVLLIIDSV SNAIRDQFIS KLLFFAFAVS ISINVYLLNA AKIHTGYMNF QPQSNKIDDL 540
VVQQKSATIE FSETRSMPAS SGLETPVTAK DIIISEEIQN NECVYALSSQ DEPIRPLSNL 600
VELMEKEQLK NMNNTEVSNL VVNGKLPLYS LEKKLEDTTR AVLVRRKALS TLAESPILVS 660
EKLPFRNYDY DRVFGACCEN VIGYMPIPVG VIGPLIIDGT SYHIPMATTE GCLVASAMRG 720
CKAINAGGGA TTVLTKDGMT RGPVVRFPTL IRSGACKIWL DSEEGQNSIK KAFNSTSRFA 780
RLQHIQTCLA GDLLFMRFRT TTGDAMGMNM ISKGVEYSLK QMVEEYGWED MEVVSVSGNY 840
CTDKKPAAIN WIEGRGKSVV AEATIPGDVV KSVLKSDVSA LVELNISKNL VGSAMAGSVG 900
GFNAHAANLV TALFLALGQD PAQNVESSNC ITLMKEVDGD LRISVSMPSI EVGTIGGGTV 960
LEPQGAMLDL LGVRGPHPTE PGANARQLAR IIACAVLAGE LSLCSALAAG HLVQSHMTHN 1020
RKTNKANELP QPSNKGPPCK TSALL 1046
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR025583--HMG-CoA_N_dom
IPR002202--HMG_CoA_Rdtase
IPR023074--HMG_CoA_Rdtase_cat
IPR023076--HMG_CoA_Rdtase_CS
IPR004554--HMG_CoA_Rdtase_eu_arc
IPR023282--HMG_CoA_Rdtase_N
IPR009023--HMG_CoA_Rdtase_NAD(P)-bd_dom
IPR009029--HMG_CoA_Rdtase_sub-bd_dom
IPR000731--SSD
PROSITE

PS00066--HMG_COA_REDUCTASE_1
PS00318--HMG_COA_REDUCTASE_2
PS01192--HMG_COA_REDUCTASE_3
PS50065--HMG_COA_REDUCTASE_4
PS50156--SSD
Pfam

PF00368--HMG-CoA_red
PF13323--HPIH
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0005635--C:nuclear envelope
GO:0005778--C:peroxisomal membrane
GO:0004420--F:hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0042282--F:hydroxymethylglutaryl-CoA reductase activity
GO:0050661--F:NADP binding
GO:0015936--P:coenzyme A metabolic process
GO:0006696--P:ergosterol biosynthetic process
GO:0008299--P:isoprenoid biosynthetic process