dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005642
Uniprot Accession P12683; HMDH1_YEAST; D6W0K8;
Genbank Protein ID NP_013636.1;
Genbank Nucleotide ID NM_001182434.1;
Protein Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Protein Synonyms/Alias
Gene Name HMG1
Gene Synonyms/Alias YML075C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
551TAPVQKASTPVLTNKPhosphoGRID 2.0;curated21126336; 25315811
552APVQKASTPVLTNKTdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 19060867; 19366988;
576LSSAQSSSSGPSSSScurated19823750; 24961812
577SSAQSSSSGPSSSSEPHOSIDA;curated21081558; 22817900; 19795423
580QSSSSGPSSSSEEDDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 16381945; 23193290; 17330950; 19779198; 21081558;
581SSSSGPSSSSEEDDSdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17563356; 16381945; 23193290; 17330950; 20702584; 19823750;
582SSSGPSSSSEEDDSRdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17330950; 16381945; 23193290; 20702584; 19823750; 19779198;
583SSGPSSSSEEDDSRDdbPTM 3.0;PhosphoGRID 2.0;PHOSIDA;SysPTM 2.0;curated17330950; 16381945; 23193290; 20702584; 19779198; 21081558;
588SSSEEDDSRDIESLDPhosphoPep 2.0;curated19060867; 24961812
593DDSRDIESLDKKIRPPhosphoPep 2.0;curated19060867; 22817900; 24961812; 25315811
609EELEALLSSGNTKQLdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
1048INRLKDGSVTCIKS-curated25315811
Sequence
(Fasta)		MPPLFKGLKQ MAKPIAYVSR FSAKRPIHII LFSLIISAFA YLSVIQYYFN GWQLDSNSVF 60
ETAPNKDSNT LFQECSHYYR DSSLDGWVSI TAHEASELPA PHHYYLLNLN FNSPNETDSI 120
PELANTVFEK DNTKYILQED LSVSKEISST DGTKWRLRSD RKSLFDVKTL AYSLYDVFSE 180
NVTQADPFDV LIMVTAYLMM FYTIFGLFND MRKTGSNFWL SASTVVNSAS SLFLALYVTQ 240
CILGKEVSAL TLFEGLPFIV VVVGFKHKIK IAQYALEKFE RVGLSKRITT DEIVFESVSE 300
EGGRLIQDHL LCIFAFIGCS MYAHQLKTLT NFCILSAFIL IFELILTPTF YSAILALRLE 360
MNVIHRSTII KQTLEEDGVV PSTARIISKA EKKSVSSFLN LSVVVIIMKL SVILLFVFIN 420
FYNFGANWVN DAFNSLYFDK ERVSLPDFIT SNASENFKEQ AIVSVTPLLY YKPIKSYQRI 480
EDMVLLLLRN VSVAIRDRFV SKLVLSALVC SAVINVYLLN AARIHTSYTA DQLVKTEVTK 540
KSFTAPVQKA STPVLTNKTV ISGSKVKSLS SAQSSSSGPS SSSEEDDSRD IESLDKKIRP 600
LEELEALLSS GNTKQLKNKE VAALVIHGKL PLYALEKKLG DTTRAVAVRR KALSILAEAP 660
VLASDRLPYK NYDYDRVFGA CCENVIGYMP LPVGVIGPLV IDGTSYHIPM ATTEGCLVAS 720
AMRGCKAINA GGGATTVLTK DGMTRGPVVR FPTLKRSGAC KIWLDSEEGQ NAIKKAFNST 780
SRFARLQHIQ TCLAGDLLFM RFRTTTGDAM GMNMISKGVE YSLKQMVEEY GWEDMEVVSV 840
SGNYCTDKKP AAINWIEGRG KSVVAEATIP GDVVRKVLKS DVSALVELNI AKNLVGSAMA 900
GSVGGFNAHA ANLVTAVFLA LGQDPAQNVE SSNCITLMKE VDGDLRISVS MPSIEVGTIG 960
GGTVLEPQGA MLDLLGVRGP HATAPGTNAR QLARIVACAV LAGELSLCAA LAAGHLVQSH 1020
MTHNRKPAEP TKPNNLDATD INRLKDGSVT CIKS 1055
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0521--NADP
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0752--Steroid biosynthesis
KW-0753--Steroid metabolism
KW-0756--Sterol biosynthesis
KW-1207--Sterol metabolism
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR025583--HMG-CoA_N_dom
IPR002202--HMG_CoA_Rdtase
IPR023074--HMG_CoA_Rdtase_cat
IPR023076--HMG_CoA_Rdtase_CS
IPR004554--HMG_CoA_Rdtase_eu_arc
IPR023282--HMG_CoA_Rdtase_N
IPR009023--HMG_CoA_Rdtase_NAD(P)-bd_dom
IPR009029--HMG_CoA_Rdtase_sub-bd_dom
IPR000731--SSD
PROSITE

PS00066--HMG_COA_REDUCTASE_1
PS00318--HMG_COA_REDUCTASE_2
PS01192--HMG_COA_REDUCTASE_3
PS50065--HMG_COA_REDUCTASE_4
PS50156--SSD
Pfam

PF00368--HMG-CoA_red
PF13323--HPIH
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0005635--C:nuclear envelope
GO:0005778--C:peroxisomal membrane
GO:0004420--F:hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0042282--F:hydroxymethylglutaryl-CoA reductase activity
GO:0050661--F:NADP binding
GO:0015936--P:coenzyme A metabolic process
GO:0006696--P:ergosterol biosynthetic process
GO:0019287--P:isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0008299--P:isoprenoid biosynthetic process