dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0005638
Uniprot Accession P12646; G6PD_DROME; Q27574; Q27872; Q27879; Q27881; Q9VWE2; Q9VWE3;
Genbank Protein ID NP_001285456.1; NP_523411.1; NP_728287.1;
Genbank Nucleotide ID NM_001298527.1; NM_078687.2; NM_167676.2;
Protein Name Glucose-6-phosphate 1-dehydrogenase
Protein Synonyms/Alias
Gene Name Zw
Gene Synonyms/Alias G6PD;CG12529;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
20LIIKSLKSPTMVCEGdbPTM 3.0;Phospho.ELM 9.0;UniProt18327897; 16381945; 23193290
Sequence
(Fasta)
MATQKEDHTA LDLIIKSLKS PTMVCEGTHF DGKIPHTFVI FGASGDLAKK KIYPTLWWLY 60
RDDLLPKPTK FCGYARSMLT VDSIKEQCLP YMKVQPHEQK KYEEFWALNE YVSGRYDGRT 120
GFELLNQQLE IMENKNKANR IFYLALPPSV FEEVTVNIKQ ICMSVCGWNR VIIEKPFGRD 180
DASSQALSDH LAGLFQEDQL YRIDHYLGKE MVQNLMTIRF GNKILSSTWN RENIASVLIT 240
FKEPFGTQGR GGYFDEFGII RDVMQNHLLQ ILSLVAMEKP VSCHPDDIRD EKVKVLKSIE 300
ALTLDDMVLG QYLGNPQGTN DDARTGYVED PTVSNDSNTP TYALGVLKIN NERWQGVPFI 360
LRCGKALNER KAEVRIQYQD VLGDIFEGNT KRNELVIRVQ PGEALYFKMM TKSPGITFDI 420
EETELDLTYE HRYKDSYLPD AYERLILDVF CGSQMHFVRS DELREAWRIF TPILHQIEKE 480
HIRPITYQYG SRGPKEADRK CEENNFKYSG SYKWHGGKAA TSNH 525
Keyword

KW-0025--Alternative splicing
KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0313--Glucose metabolism
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR001282--G6P_DH
IPR019796--G6P_DH_AS
IPR022675--G6P_DH_C
IPR022674--G6P_DH_NAD-bd
IPR016040--NAD(P)-bd_dom

PROSITE

PS00069--G6P_DEHYDROGENASE

Pfam

PF02781--G6PD_C
PF00479--G6PD_N

Gene Ontology

GO:0004345--F:glucose-6-phosphate dehydrogenase activity
GO:0050661--F:NADP binding
GO:0051156--P:glucose 6-phosphate metabolic process
GO:0006006--P:glucose metabolic process
GO:0006739--P:NADP metabolic process
GO:0006098--P:pentose-phosphate shunt