dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005634
Uniprot Accession P12613; TCPA_DROME; Q9VCZ6;
Genbank Protein ID NP_524450.2; NP_732748.1;
Genbank Nucleotide ID NM_079726.4; NM_170016.2;
Protein Name T-complex protein 1 subunit alpha
Protein Synonyms/Alias
Gene Name T-cp1
Gene Synonyms/Alias CCT-1;Tcp-1;CG5374;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
6--MSTLASPLSIAGTPHOSIDA21081558
30QNVMAALSISNIVKSPhosphoPep 2.0;curated19060867; 22817900
150VDELGRDSLINIAKTPhosphoPep 2.0;curated19060867; 22817900
542KLNPEDKSGKSYADAcurated22817900
545PEDKSGKSYADACAAdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MSTLASPLSI AGTRQSGASV RTQNVMAALS ISNIVKSSLG PVGLDKMLVD DIGDVTVTND 60
GATILRLLEV EHPAAKVLVE LAQLQDEEVG DGTTSVVILA AELLKNADEL VKQKIHPTSI 120
ISGYRIACKE ACKYISEHLT APVDELGRDS LINIAKTSMS SKIIGADAEF FSAMVVDAAQ 180
SVKITDPRGQ AAYSIKAINV LKAHGKSARE SVLIPGYALN CTIASQQMPK KIVNAKIACL 240
DFSLQKTKMK MGVQVLINDP DKLEAIRARE LDITKERINM ILGTGVNVVL VSGGVDDLCM 300
KYFVEAGAMA VRRVKKSDLK IIAKATGAAF ITSLTNMDGE ESFDASMVGE AAEVAQERIC 360
DDELILIKGT KARAAASIIL RGPNDFYCDE MERSVHDALC VVKRVLESKK VVAGGGCVEA 420
ALSIYLENFA TSLASREQLA IAEFAKSLLV IPKTLSVNAA KDATDLVAKL RSYHNSSQTK 480
PERSDLKWTG LDLIEGVVRD NKKAGVLEPA MSKIKSLKFA TEAAITILRI DDMIKLNPED 540
KSGKSYADAC AAGELDG 558
Keyword

KW-0067--ATP-binding
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
Interpro

IPR012715--Chap_CCT_alpha
IPR017998--Chaperone_TCP-1
IPR002194--Chaperonin_TCP-1_CS
IPR002423--Cpn60/TCP-1
IPR027409--GroEL-like_apical_dom
IPR027413--GROEL-like_equatorial
IPR027410--TCP-1-like_intermed
PROSITE

PS00750--TCP1_1
PS00751--TCP1_2
PS00995--TCP1_3
Pfam

PF00118--Cpn60_TCP1
Gene Ontology

GO:0005829--C:cytosol
GO:0005875--C:microtubule associated complex
GO:0005753--C:mitochondrial proton-transporting ATP synthase complex
GO:0005524--F:ATP binding
GO:0008553--F:hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:1902600--P:hydrogen ion transmembrane transport
GO:0090307--P:mitotic spindle assembly
GO:0007052--P:mitotic spindle organization
GO:0006909--P:phagocytosis
GO:0006457--P:protein folding