dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005632
Uniprot Accession P12611; WHI2_YEAST; D6W2A9; Q08413;
Genbank Protein ID NP_014686.1;
Genbank Nucleotide ID NM_001183462.1;
Protein Name Growth regulation protein
Protein Synonyms/Alias
Gene Name WHI2
Gene Synonyms/Alias YOR043W;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
130KFFDRPSSSFVSNAKdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22369663; 22817900; 25315811
131FFDRPSSSFVSNAKGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17563356; 18407956; 16381945; 23193290; 19366988; 22369663;
134RPSSSFVSNAKGFFGcurated22369663; 24961812
143AKGFFGLSSNNSISScurated19823750
144KGFFGLSSNNSISSNcurated19823750
150SSNNSISSNNEQDILcurated22369663
325PSQDNFITPMQSNIScurated24961812
329NFITPMQSNISINSLcurated24961812
332TPMQSNISINSLSAScurated24961812
335QSNISINSLSASKSNcurated24961812
339SINSLSASKSNSTIScurated24961812
341NSLSASKSNSTISTAcurated19823750; 24961812; 25315811
343LSASKSNSTISTARNcurated19823750; 24961812; 25315811
344SASKSNSTISTARNLcurated24961812
346SKSNSTISTARNLTScurated24961812
347KSNSTISTARNLTSGcurated24961812
380ADNVRSHSSSRHSSQdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 22817900; 24961812;
381DNVRSHSSSRHSSQTcurated24961812; 20377248
382NVRSHSSSRHSSQTRcurated24961812; 20377248
385SHSSSRHSSQTRSKPcurated24961812; 20377248
Sequence
(Fasta)		MDDIITQVSP DNAESAPILQ EQQQQQNSQY EGNEEDYGDS LIHLNIQENH YFITRDQLMS 60
LPESLLLCLF PSGVFLDRCG QVITNLTRDD EVYIVNFPPD CFEYIMEIYT KAHDDLYNHP 120
VEKFFDRPSS SFVSNAKGFF GLSSNNSISS NNEQDILHQK PAIIVLREDL DYYCVPQEEF 180
QFDSTNEENN EDLLRHFMAQ VKMAAGSYLT SKTSIFQGLY SSNRLKQQQQ QQKIEKGSNS 240
SSNTKSTSKK LGPAEQHLMD MLCSSGFTKE TCWGNRTQET GKTVISSLSL CRLANETTEG 300
FRQKFNEAKA KWEAEHKPSQ DNFITPMQSN ISINSLSASK SNSTISTARN LTSGSTAPAT 360
ARDKRKSRLS KLADNVRSHS SSRHSSQTRS KPPELPKLYD LVPKPNINAK LLLFWRKPAR 420
KCWWGEEDIE LEVEVFGSWK DESKKIIELI LPTNVDPEAE LHKIIVPVRL HIRRVWTLEL 480
SVIGVQ 487
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR011333--POZ_dom
PROSITE
Pfam
Gene Ontology

GO:0019211--F:phosphatase activator activity
GO:0007015--P:actin filament organization
GO:0007049--P:cell cycle
GO:0006897--P:endocytosis
GO:0000422--P:mitophagy
GO:0043085--P:positive regulation of catalytic activity
GO:0040008--P:regulation of growth
GO:0009408--P:response to heat
GO:0009651--P:response to salt stress