dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005623
Uniprot Accession P12383; PDR1_YEAST; D6VUC4;
Genbank Protein ID NP_011502.1;
Genbank Nucleotide ID NM_001180878.1;
Protein Name Transcription factor PDR1
Protein Synonyms/Alias Pleiotropic drug resistance protein 1;
Gene Name PDR1
Gene Synonyms/Alias AMY1;ANT1;BOR2;CYH3;NRA2;SMR2;TIL1;TPE1;TPE3;YGL013C;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Positive regulator of proteins involved in permeability. PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
21TGPDTESSADSSNFSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19779198; 19366988; 22817900
110DSSSTSFSNPQRCTDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988
138NFKLGGRSSGDNSGSdbPTM 3.0;PhosphoGRID 2.0;curated17563356; 16381945; 23193290; 22817900
145SSGDNSGSDGKNDDDcurated25315811
342QKMNLLPSTPSSISSPhosphoPep 2.0;curated19060867; 26040289; 26447709
343KMNLLPSTPSSISSAPhosphoPep 2.0;curated19060867; 24961812; 25315811
345NLLPSTPSSISSAGScurated26447709
346LLPSTPSSISSAGSPcurated25315811
348PSTPSSISSAGSPNTdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26447709
349STPSSISSAGSPNTAcurated26447709
352SSISSAGSPNTAHTKPhosphoPep 2.0;curated19060867; 24961812; 25315811
358GSPNTAHTKSHVALVPhosphoGRID 2.019779198
930CLLNGIESPQLPFNGdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 26040289
939QLPFNGRSAPSPVRNPhosphoPep 2.0;curated19060867; 23607784
942FNGRSAPSPVRNNSLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 17563356; 16381945; 23193290; 17330950; 19779198;
948PSPVRNNSLPEFAQLdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 18407956; 16381945; 23193290; 20702584; 19779198;
957PEFAQLPSFRSLSVSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26447709
Sequence
(Fasta)		MRGLTPKNGV HIETGPDTES SADSSNFSTG FSGKIRKPRS KVSKACDNCR KRKIKCNGKF 60
PCASCEIYSC ECTFSTRQGG ARIKNLHKTS LEGTTVQVKE ETDSSSTSFS NPQRCTDGPC 120
AVEQPTKFFE NFKLGGRSSG DNSGSDGKND DDVNRNGFYE DDSESQATLT SLQTTLKNLK 180
EMAHLGTHVT SAIESIELQI SDLLKRWEPK VRTKELATTK FYPNKSIETQ LMKNKYCDVV 240
HLTRYAAWSN NKKDQDTSSQ PLIDEIFGLY SPFQFLSLQG IGKCFQNYRS KSKCEIFPRT 300
AKETIYIMLR FFDVCFHHIN QGCVSIANPL ENYLQKMNLL PSTPSSISSA GSPNTAHTKS 360
HVALVINHLP QPFVRNITGI SNSELLSEMN NDISMFGILL KMLDMHKNSY QNFLMEITSN 420
PSVAKNTQSI DVLQEFIHYC QAGEALIALC YSYYNSTLYN YVDFTCDITH LEQLLYFLDL 480
LFWLSEIYGF EKVLNVAVHF VSRVGLSRWE FYVGLDENFA ERRRNLWWKA FYFEKTLASK 540
LGYPSNIDDS KINCLLPKNF RDVGFLDNRD FIENVHLVRR SEAFDNMCIS DLKYYGELAV 600
LQIVSHFSSS VLFNEKFTSI RNTSKPSVVR EKLLFEVLEI FNETEMKYDA IKEQTGKLFD 660
IAFSKDSTEL KVSREDKIMA SKFVLFYEHH FCRMVNESDN IVARLCVHRR PSILIENLKI 720
YLHKIYKSWT DMNKILLDFD NDYSVYRSFA HYSISCIILV SQAFSVAEFI KVNDVVNMIR 780
VFKRFLDIKI FSENETNEHV FNSQSFKDYT RAFSFLTIVT RIMLLAYGES SSTNLDVISK 840
YIDENAPDLK GIIELVLDTN SCAYRFLLEP VQKSGFHLTV SQMLKNRKFQ EPLMSNEDNK 900
QMKHNSGKNL NPDLPSLKTG TSCLLNGIES PQLPFNGRSA PSPVRNNSLP EFAQLPSFRS 960
LSVSDMINPD YAQPTNGQNN TQVQSNKPIN AQQQIPTSVQ VPFMNTNEIN NNNNNNNNNK 1020
NNINNINNNN SNNFSATSFN LGTLDEFVNN GDLEDLYSIL WSDVYPDS 1069
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
Interpro

IPR007219--Transcription_factor_dom_fun
IPR001138--Zn2-C6_fun-type_DNA-bd
PROSITE

PS00463--ZN2_CY6_FUNGAL_1
PS50048--ZN2_CY6_FUNGAL_2
Pfam

PF04082--Fungal_trans
PF00172--Zn_clus
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:2001040--P:positive regulation of cellular response to drug
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter