dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005605
Uniprot Accession P12252; PDE4B_DROME; M9PGD1; M9PGX1; O76918; Q8IRU3; Q8IRU6; Q8IRU8; Q8IRV0; Q8MRN3; Q8T8M0; Q9NF62; Q9W4S8; Q9W4T0; Q9W4T1;
Genbank Protein ID NP_001259201.1; NP_001259202.1; NP_001259203.1; NP_726849.1; NP_726850.1; NP_726851.3; NP_726852.2; NP_726853.2; NP_726854.2; NP_726855.1; NP_726857.1; NP_726859.2;
Genbank Nucleotide ID NM_001272272.1; NM_001272273.1; NM_001272274.1; NM_166961.2; NM_166962.2; NM_166963.2; NM_166964.2; NM_166965.2; NM_166966.3; NM_166967.2; NM_166969.2; NM_166971.2;
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase
Protein Synonyms/Alias Learning/memory process protein;Protein dunce;
Gene Name dnc
Gene Synonyms/Alias CG32498;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
48MADLELGSPEKQVQVPHOSIDA21081558
246VRSTSAHSEAAAGVAPHOSIDA21081558
349NRKITILSPIHAPPGPHOSIDA21081558
368LKRAQGRSPLSPRISPHOSIDA21081558
371AQGRSPLSPRISFPGPHOSIDA21081558
Sequence
(Fasta)		MSQESNGGPA AGGGAAAAPP PPPQYIITTP SEVDPDEVRS MADLELGSPE KQVQVQSQKF 60
SSTSSTTKVA THSFSMSSSA GTTGQQSKQD SAQQIQQLQQ LQQLQQLQQQ QQQQQSQRII 120
SSSTRSQSLQ SSTIVGEATT ITSGAAQILS ASAAASLAQQ LKAQSSTSII TSSEQRTSTS 180
TSSSSSTRYI ASGSSNLAGG NSNSASSASS KTRFQSFLQQ PEGAHGFLTA HQKHVRQFVR 240
STSAHSEAAA GVAGARAEKC IRSASTQIDD ASVAGVVESA GNLTDSSATG GSMQLSMSKL 300
GLQQSSSILI SKSAETIEMK SSSAGMRTQL TLSGGFLAPP GNRKITILSP IHAPPGLHDM 360
LKRAQGRSPL SPRISFPGSD SDLFGFDVEN GQGARSPLEG GSPSAGLVLQ NLPQRRESFL 420
YRSDSDFEMS PKSMSRNSSI ASERFKEQEA SILVDRSHGE DLIVTPFAQI LASLRSVRNN 480
LLSLTNVPAS NKSRRPNQSS SASRSGNPPG APLSQGEEAY TRLATDTIEE LDWCLDQLET 540
IQTHRSVSDM ASLKFKRMLN KELSHFSESS RSGNQISEYI CSTFLDKQQE FDLPSLRVED 600
NPELVAANAA AGQQSAGQYA RSRSPRGPPM SQISGVKRPL SHTNSFTGER LPTFGVETPR 660
ENELGTLLGE LDTWGIQIFS IGEFSVNRPL TCVAYTIFQS RELLTSLMIP PKTFLNFMST 720
LEDHYVKDNP FHNSLHAADV TQSTNVLLNT PALEGVFTPL EVGGALFAAC IHDVDHPGLT 780
NQFLVNSSSE LALMYNDESV LENHHLAVAF KLLQNQGCDI FCNMQKKQRQ TLRKMVIDIV 840
LSTDMSKHMS LLADLKTMVE TKKVAGSGVL LLDNYTDRIQ VLENLVHCAD LSNPTKPLPL 900
YKRWVALLME EFFLQGDKER ESGMDISPMC DRHNATIEKS QVGFIDYIVH PLWETWADLV 960
HPDAQDILDT LEENRDYYQS MIPPSPPPSG VDENPQEDRI RFQVTLEESD QENLAELEEG 1020
DESGGESTTT GTTGTTAASA LSGAGGGGGG GGGMAPRTGG CQNQPQHGGM 1071
Keyword

KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0114--cAMP
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
Interpro

IPR003607--HD/PDEase_dom
IPR023088--PDEase
IPR002073--PDEase_catalytic_dom
IPR023174--PDEase_CS
PROSITE

PS00126--PDEASE_I
Pfam

PF00233--PDEase_I
Gene Ontology

GO:0005622--C:intracellular
GO:0004114--F:3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0046872--F:metal ion binding
GO:0008306--P:associative learning
GO:0048675--P:axon extension
GO:0048149--P:behavioral response to ethanol
GO:0006198--P:cAMP catabolic process
GO:0019933--P:cAMP-mediated signaling
GO:0007623--P:circadian rhythm
GO:0001661--P:conditioned taste aversion
GO:0007619--P:courtship behavior
GO:0046331--P:lateral inhibition
GO:0007612--P:learning
GO:0007611--P:learning or memory
GO:0045475--P:locomotor rhythm
GO:0007617--P:mating behavior
GO:0007613--P:memory
GO:0046958--P:nonassociative learning
GO:0008355--P:olfactory learning
GO:0048477--P:oogenesis
GO:0010738--P:regulation of protein kinase A signaling
GO:0000003--P:reproduction
GO:0007614--P:short-term memory
GO:0007268--P:synaptic transmission
GO:0040040--P:thermosensory behavior