dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005580
Uniprot Accession P11978; SIR4_YEAST; D6VSK9;
Genbank Protein ID NP_010513.1;
Genbank Nucleotide ID NM_001180535.1;
Protein Name Regulatory protein SIR4
Protein Synonyms/Alias Silent information regulator 4;
Gene Name SIR4
Gene Synonyms/Alias ASD1;STE9;UTH2;YDR227W;YD9934.12;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
Phosphorylation Sites
 dbPAF PTMs: 34 (View all)
PositionPeptidesSourceReferences ( PMIDs )
22KFTKKPVTPNDKIPEPhosphoPep 2.0;curated19060867; 25315811; 20377248
39EKSNEVKTPKIPLFTPhosphoPep 2.019060867
62RPSTAIHTSPHQPSDdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated17287358; 16381945; 23193290; 19366988; 25704821; 22817900
63PSTAIHTSPHQPSDVcurated25704821
83KQLQQPKSSPLKKNNPhosphoGRID 2.0;curated19823750; 19795423; 25704821; 22817900; 20377248
84QLQQPKSSPLKKNNYPhosphoGRID 2.0;curated19823750; 19795423; 25704821; 22817900; 20377248
91SPLKKNNYNSFPHSNcurated25315811
171STSQTNNSFLSGVKScurated24961812
266SAGDSGISPEESKARPhosphoPep 2.0;curated19060867; 26040289; 25315811
274PEESKARSPGIAKPNdbPTM 3.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19366988; 26040289; 24961812;
342TSKKIVPSPKKVAIDdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 19779198; 19060867; 19366988;
389KRMEILKSPHLSKSPPhosphoGRID 2.0;PhosphoPep 2.0;curated19779198; 19060867; 25704821; 19823750
395KSPHLSKSPADRPQGPhosphoPep 2.0;curated19060867; 25704821; 25315811
506QGESHIDSRNNTLNVcurated22817900
514RNNTLNVTPSKRPQLPhosphoGRID 2.0;PhosphoPep 2.0;curated19520826; 19060867; 22369663; 24961812; 25315811
516NTLNVTPSKRPQLGEPhosphoPep 2.019060867
567DILHTKESSNEAKKTcurated26040406
611NDLFQVESAPKISSEcurated22369663; 25315811
639SKAVESKSLLNLFSNcurated22369663; 24961812
692KTDKVSLSQPVSASKdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 20190278; 19366988; 22817900;
Sequence
(Fasta)		MPNDNKTPNR SSTPKFTKKP VTPNDKIPER EEKSNEVKTP KIPLFTFAKS KNYSRPSTAI 60
HTSPHQPSDV KPTSHKQLQQ PKSSPLKKNN YNSFPHSNLE KISNSKLLSL LRSKTSAGRI 120
ESNNPSHDAS RSLASFEQTA FSRHAQQQTS TFNSKPVRTI VPISTSQTNN SFLSGVKSLL 180
SEEKIRDYSK EILGINLANE QPVLEKPLKK GSADIGASVI SLTKDKSIRK DTVEEKKEEK 240
LNIGKNFAHS DSLSVPKVSA GDSGISPEES KARSPGIAKP NAIQTEVYGI NEESTNERLE 300
INQEKPVKLD ENSANSTVAS ALDTNGTSAT TETLTSKKIV PSPKKVAIDQ DKITLHDEKT 360
LAPSKHQPIT SEQKMKEDAD LKRMEILKSP HLSKSPADRP QGRRNSRNFS TRDEETTKLA 420
FLVEYEGQEN NYNSTSRSTE KKNDMNTSAK NKNGENKKIG KRPPEIMSTE AHVNKVTEET 480
TKQIQSVRID GRKVLQKVQG ESHIDSRNNT LNVTPSKRPQ LGEIPNPMKK HKPNEGRTPN 540
ISNGTINIQK KLEPKEIVRD ILHTKESSNE AKKTIQNPLN KSQNTALPST HKVTQKKDIK 600
IGTNDLFQVE SAPKISSEID RENVKSKDEP VSKAVESKSL LNLFSNVLKA PFIKSESKPF 660
SSDALSKEKA NFLETIASTE KPENKTDKVS LSQPVSASKH EYSDNFPVSL SQPSKKSFAN 720
HTEDEQIEKK KICRGRMNTI ITHPGKMELV YVSDSDDSSS DNDSLTDLES LSSGESNEIK 780
VTNDLDTSAE KDQIQAGKWF DPVLDWRKSD RELTKNILWR IADKTTYDKE TITDLIEQGI 840
PKHSYLSGNP LTSVTNDICS VENYETSSAF FYQQVHKKDR LQYLPLYAVS TFENTNNTEK 900
NDVTNKNINI GKHSQEQNSS SAKPSQIPTV SSPLGFEETK LSTTPTKSNR RVSHSDTNSS 960
KPKNTKENLS KSSWRQEWLA NLKLISVSLV DEFPSELSDS DRQIINEKMQ LLKDIFANNL 1020
KSAISNNFRE SDIIILKGEI EDYPMSSEIK IYYNELQNKP DAKKARFWSF MKTQRFVSNM 1080
GFDIQKSCEP VSISTSVKPH VVEPEHMADA KIMPKDILQI TKKPLMVKNV KPSSPPDVKS 1140
LVQLSTMETK TLPEKKQFDS IFNSNKAKII PGNGKHASEN ISLSFSRPAS YGYFSVGKRV 1200
PIVEDRRVKQ LDDITDSNTT EILTSVDVLG THSQTGTQQS NMYTSTQKTE LEIDNKDSVT 1260
ECSKDMKEDG LSFVDIVLSK AASALDEKEK QLAVANEIIR SLSDEVMRNE IRITSLQGDL 1320
TFTKKCLENA RSQISEKDAK INKLMEKDFQ VNKEIKPY 1359
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR031556--SIR4_SID
PROSITE
Pfam

PF16991--SIR4_SID
Gene Ontology

GO:0005677--C:chromatin silencing complex
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005724--C:nuclear telomeric heterochromatin
GO:0003690--F:double-stranded DNA binding
GO:0031491--F:nucleosome binding
GO:0006342--P:chromatin silencing
GO:0001308--P:negative regulation of chromatin silencing involved in replicative cell aging
GO:0006351--P:transcription, DNA-templated