dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0005579
Uniprot Accession P11972; SST2_YEAST; D6VZ86; Q06207;
Genbank Protein ID NP_013557.1;
Genbank Nucleotide ID NM_001182340.1;
Protein Name Protein SST2
Protein Synonyms/Alias
Gene Name SST2
Gene Synonyms/Alias YLR452C;L9324.9;
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)(Baker's yeast)
NCBI Taxa ID 559292
Functional Description
(View all)		 Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
88LKVDMNTTCINVSYNcurated25492886
93NTTCINVSYNIKPSLcurated25492886
252INDLERVSPLAHRFFdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17330950; 16381945; 23193290; 19060867; 19366988; 22817900
380NIRAPNGSTIDLDFTdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;curated15665377; 18407956; 16381945; 23193290; 11875433; 19366988;
408LDDSEGFSQDMLISSdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.0;UniProt;curated18407956; 16381945; 23193290; 19366988; 22817900; 19547744
539DIMLHPHSPLSEHFPdbPTM 3.0;PhosphoGRID 2.0;SysPTM 2.010593933; 18407956; 16381945; 23193290; 15924435; 19366988
587LKPSKNLSNENCSFKdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated15665377; 17330950; 17563356; 18407956; 16381945; 23193290;
592NLSNENCSFKKQGFKdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated15665377; 18407956; 16381945; 23193290; 19684113; 19823750;
611EYKPAPLTLAETHSPPhosphoPep 2.019060867
615APLTLAETHSPNASVdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated17330950; 16381945; 23193290; 19060867; 19366988; 26040289
617LTLAETHSPNASVENdbPTM 3.0;PhosphoGRID 2.0;PhosphoPep 2.0;SysPTM 2.0;curated18407956; 16381945; 23193290; 17330950; 19060867; 19366988;
621ETHSPNASVENSHTIdbPTM 3.0;PhosphoPep 2.0;SysPTM 2.0;curated17330950; 16381945; 23193290; 19060867; 19366988; 26040289;
Sequence
(Fasta)		MVDKNRTLHE LSSKNFSRTP NGLIFTNDLK TVYSIFLICL DLKEKKHSSD TKSFLLTAFT 60
KHFHFTFTYQ EAIKAMGQLE LKVDMNTTCI NVSYNIKPSL ARHLLTLFMS SKLLHTPQDR 120
TRGEPKEKVL FQPTPKGVAV LQKYVRDIGL KTMPDILLSS FNSMKLFTFE RSSVTDSIIH 180
SDYLIHILFI KMMGAKPNVW SPTNADDPLP CLSSLLEYTN NDDTFTFEKS KPEQGWQAQI 240
GNIDINDLER VSPLAHRFFT NPDSESHTQY YVSNAGIRLF ENKTFGTSKK IVIKYTFTTK 300
AIWQWIMDCT DIMHVKEAVS LAALFLKTGL IVPVLLQPSR TDKKKFQISR SSFFTLSKRG 360
WDLVSWTGCK SNNIRAPNGS TIDLDFTLRG HMTVRDEKKT LDDSEGFSQD MLISSSNLNK 420
LDYVLTDPGM RYLFRRHLEK ELCVENLDVF IEIKRFLKKM TILKKLIDSK HCDKKSNTST 480
SKNNIVKTID SALMKQANEC LEMAYHIYSS YIMIGSPYQL NIHHNLRQNI SDIMLHPHSP 540
LSEHFPTNLY DPSPASAESA ASSISSTEAD TLGEPPEVSL KPSKNLSNEN CSFKKQGFKH 600
QLKEYKPAPL TLAETHSPNA SVENSHTIVR YGMDNTQNDT KSVESFPATL KVLRKLYPLF 660
EIVSNEMYRL MNNDSFQKFT QSDVYKDASA LIEIQEKC 699
Keyword

KW-0181--Complete proteome
KW-0589--Pheromone response
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor
Interpro

IPR000591--DEP_dom
IPR016137--RGS
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50186--DEP
PS50132--RGS
Pfam

PF00610--DEP
PF00615--RGS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0000754--P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
GO:0035556--P:intracellular signal transduction
GO:0009968--P:negative regulation of signal transduction
GO:0043547--P:positive regulation of GTPase activity
GO:0007165--P:signal transduction